{"id":"W2953167359","doi":"10.1002/pro.3667","title":"The role of protein complexes in human genetic disease","year":2019,"lang":"en","type":"review","venue":"Protein Science","topic":"Genomics and Rare Diseases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":100,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Medical Research Council; Lister Institute of Preventive Medicine; Medical Research Council Canada; Wellcome Trust","keywords":"Human disease; Disease; Genetics; Computational biology; Chemistry; Biology; Evolutionary biology; Medicine; Gene; Internal medicine","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006596564,0.001163885,0.001802366,0.00221254,0.0004342023,0.001326995,0.001058889,0.002166003,0.002591798],"category_scores_gemma":[0.0006858423,0.0003560503,0.0005745399,0.001640902,0.001066246,0.001623068,0.001215995,0.002339408,0.002583303],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001192646,"about_ca_system_score_gemma":0.0010585,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001306874,"about_ca_topic_score_gemma":0.001207363,"domain_scores_codex":[0.9996623,0.00006711107,0.00005782688,0.0000623432,0.0001125635,0.00003790904],"domain_scores_gemma":[0.9996538,0.0001927379,0.00004462591,0.00001265052,0.00006523532,0.00003102511],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00009596623,0.00005667712,0.0002697558,0.01919615,0.0001325888,0.000771495,0.0001332929,0.000577427,0.002579588,0.01685363,0.04718019,0.9121532],"study_design_scores_gemma":[0.00001017832,0.00004558015,0.0003954044,0.00190727,0.00006020088,0.002702472,0.00004034898,0.00006669549,0.0005207096,0.004771572,0.9894629,0.00001677194],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00005127331,0.998934,0.0001078597,0.0001963307,0.0001685541,0.000001845379,0.000006791816,0.000005680433,0.0005278469],"genre_scores_gemma":[0.0005258892,0.9986199,0.00009401961,0.000195117,0.0001625651,0.000004292731,0.00001726419,0.000001524883,0.0003793602],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002591798,"threshold_uncertainty_score":0.00867039,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02152359827763698,"score_gpt":0.3116815134298155,"score_spread":0.2901579151521785,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}