{"id":"W2953167359","doi":"10.1002/pro.3667","title":"The role of protein complexes in human genetic disease","year":2019,"lang":"en","type":"review","venue":"Protein Science","topic":"Genomics and Rare Diseases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":100,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Medical Research Council; Lister Institute of Preventive Medicine; Medical Research Council Canada; Wellcome Trust","keywords":"Human disease; Disease; Genetics; Computational biology; Chemistry; Biology; Evolutionary biology; Medicine; Gene; Internal medicine","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000362439,0.0002172557,0.0003775556,0.00008904453,0.0001864328,0.00006769568,0.001182021,0.0000773237,0.000005167132],"category_scores_gemma":[0.0001355113,0.0001426476,0.0001943969,0.0002834781,0.0006169909,0.000003227837,0.0004251768,0.000100556,0.00001036109],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002589703,"about_ca_system_score_gemma":0.000990596,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002848624,"about_ca_topic_score_gemma":0.00001331371,"domain_scores_codex":[0.9983935,0.00008697469,0.0003885612,0.0005317456,0.000264638,0.0003345162],"domain_scores_gemma":[0.9987403,0.000008425716,0.000265524,0.0007803066,0.00008310642,0.000122315],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00002489541,0.0001633968,0.0001262556,0.005066852,0.00003176564,0.000009127074,0.00001802966,0.00001150491,0.1305449,0.001984295,0.00001356809,0.8620055],"study_design_scores_gemma":[0.0001148259,0.0001123813,0.0002231001,0.002143609,0.0000509499,0.000003638111,0.00001772474,0.00001041577,0.005286099,0.001041109,0.9906471,0.0003490266],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.01786068,0.9797429,0.000004929023,0.000006401926,0.00003327584,0.002045535,0.0000524472,0.000003215023,0.0002506459],"genre_scores_gemma":[0.08627705,0.9122623,0.0001831526,0.000007731759,0.00008763578,0.0006066313,0.00004610082,0.00003325565,0.0004961052],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9906335,"threshold_uncertainty_score":0.5816999,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02152359827763698,"score_gpt":0.3116815134298155,"score_spread":0.2901579151521785,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}