{"id":"W2953196368","doi":"10.1136/annrheumdis-2019-eular.5529","title":"FRI0195 EFFICACY AND SAFETY OF DAPIROLIZUMAB PEGOL (DZP) IN PATIENTS WITH MODERATELY TO SEVERELY ACTIVE SYSTEMIC LUPUS ERYTHEMATOSUS (SLE): A RANDOMISED, PLACEBO (PBO)-CONTROLLED STUDY","year":2019,"lang":"en","type":"article","venue":"Annals of the Rheumatic Diseases","topic":"Monoclonal and Polyclonal Antibodies Research","field":"Medicine","cited_by":22,"is_retracted":false,"has_abstract":false,"ca_institutions":"Toronto Western Hospital","funders":"","keywords":"Medicine; CD40; Systemic lupus erythematosus; Clinical endpoint; Placebo; Prednisone; Internal medicine; Interim analysis; Immunology; Gastroenterology; Randomized controlled trial; Chemistry; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001341633,0.001204552,0.003287839,0.0004052673,0.0003767702,0.001191312,0.0009160339,0.002114485,0.005051394],"category_scores_gemma":[0.001447071,0.0007025177,0.001872019,0.0003881721,0.001322774,0.001056181,0.0004039888,0.002462073,0.0009485286],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000572225,"about_ca_system_score_gemma":0.000587501,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007381587,"about_ca_topic_score_gemma":0.001033571,"domain_scores_codex":[0.9993364,0.0003226069,0.00005390932,0.0001237277,0.00005097844,0.0001122859],"domain_scores_gemma":[0.9991991,0.000272608,0.0001543003,0.00005821331,0.00004270003,0.0002731737],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9829767,0.002475412,0.0005448015,0.0005638529,0.0008230719,0.00004520594,0.00003270174,0.0001244986,0.003071146,0.00004740204,0.0002092941,0.009085979],"study_design_scores_gemma":[0.9026608,0.09149792,0.003601818,0.00003484853,0.0007966419,0.00005034092,0.00003486112,0.0002276795,0.0004786226,0.00007118876,0.0005240111,0.00002127131],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9876913,0.008518206,0.0003918592,0.0003833332,0.0003866362,0.0007604358,0.0006111933,0.00007570912,0.001181307],"genre_scores_gemma":[0.9945463,0.002237465,0.0003862702,0.0004542367,0.0002957404,0.0004433548,0.0004638486,0.000009508284,0.001163429],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005051394,"threshold_uncertainty_score":0.01689863,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01669393433511525,"score_gpt":0.2857371550717819,"score_spread":0.2690432207366667,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}