{"id":"W2953210514","doi":"10.1136/annrheumdis-2019-eular.1762","title":"FRI0435 INFLUENCE OF BASELINE DEMOGRAPHICS AND DISEASE CHARACTERISTICS ON EFFICACY OF AN ORAL, SELECTIVE TYK2 INHIBITOR, BMS-986165, IN PATIENTS WITH PLAQUE PSORIASIS IN A PHASE 2 TRIAL","year":2019,"lang":"en","type":"article","venue":"Annals of the Rheumatic Diseases","topic":"Psoriasis: Treatment and Pathogenesis","field":"Immunology and Microbiology","cited_by":2,"is_retracted":false,"has_abstract":false,"ca_institutions":"Queen's University; Probity Medical Research","funders":"Medac; Celgene; Sanofi; Amgen; Pfizer; Eli Lilly and Company","keywords":"Medicine; Placebo; Internal medicine; Psoriasis Area and Severity Index; Psoriasis; Dermatology Life Quality Index; Clinical endpoint; Body surface area; Gastroenterology; Randomized controlled trial; Disease; Immunology; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00129659,0.001065946,0.002013739,0.0002856168,0.0002703936,0.001090718,0.0005411524,0.0009788624,0.003668962],"category_scores_gemma":[0.00114833,0.0003262481,0.001807872,0.0003369082,0.0004582624,0.0007375772,0.0002360365,0.002322911,0.000693277],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004619736,"about_ca_system_score_gemma":0.0006512922,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004566433,"about_ca_topic_score_gemma":0.00121289,"domain_scores_codex":[0.9996297,0.0001632186,0.00002889798,0.0000604884,0.00003699596,0.0000806474],"domain_scores_gemma":[0.99953,0.0001345245,0.00009004321,0.0000322337,0.00003039644,0.000182784],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.8884634,0.006965609,0.004255064,0.001024976,0.004402871,0.000112194,0.00009943126,0.001099064,0.01228498,0.0002637423,0.002469897,0.07855872],"study_design_scores_gemma":[0.7431708,0.2246121,0.0229602,0.00008711944,0.002613847,0.0002075619,0.00008558966,0.001274821,0.001584999,0.0003232052,0.003027935,0.00005176168],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9877427,0.007768355,0.000268996,0.0006880616,0.0002887037,0.0003893308,0.0007637542,0.00009975726,0.001990333],"genre_scores_gemma":[0.9921233,0.002918927,0.0004931521,0.0007791687,0.0002872712,0.000548911,0.0009849367,0.00001998592,0.001844262],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003668962,"threshold_uncertainty_score":0.01227391,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01531817242361195,"score_gpt":0.2694542150419018,"score_spread":0.2541360426182898,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}