{"id":"W2953220484","doi":"10.1002/glia.23645","title":"Glial<i>HMOX1</i>expression promotes central and peripheral α‐synuclein dysregulation and pathogenicity in parkinsonian mice","year":2019,"lang":"en","type":"article","venue":"Glia","topic":"Parkinson's Disease Mechanisms and Treatments","field":"Medicine","cited_by":35,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Jewish General Hospital","funders":"Fonds de Recherche du Québec - Santé; Canadian Institutes of Health Research","keywords":"HMOX1; Biology; Substantia nigra; Cell biology; Molecular biology; Endocrinology; Internal medicine; Dopaminergic; Heme oxygenase; Dopamine; Heme; Medicine; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0000873125,0.000162375,0.0002366449,0.00005454654,0.00005196279,0.00003062797,0.00003235263,0.00009532467,0.0001022929],"category_scores_gemma":[0.00001750992,0.0001370516,0.00003764813,0.00007361216,0.00002914252,0.0001291956,0.0000430006,0.00009152864,0.00001076995],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006862199,"about_ca_system_score_gemma":0.00003479793,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00009272006,"about_ca_topic_score_gemma":0.00004142513,"domain_scores_codex":[0.9989848,0.00004867223,0.0001609537,0.0003618189,0.000163993,0.0002797435],"domain_scores_gemma":[0.9995567,0.00001417125,0.00005558284,0.0001618876,0.00002221245,0.0001894527],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0006124162,0.0003319133,0.8283592,0.0001457406,0.00003926497,0.0001091763,0.0008676437,0.00000714515,0.1516026,0.0001254511,0.00005367255,0.01774582],"study_design_scores_gemma":[0.003649847,0.0002800298,0.9794776,0.000210515,0.00005963686,0.000029715,0.00007866336,0.003170223,0.01078744,0.0002870001,0.001813289,0.0001560573],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9981136,0.0006084215,0.00002219905,0.0001803045,0.0001190904,0.0005530652,0.00002789829,0.00003629159,0.0003391684],"genre_scores_gemma":[0.9984941,0.00007759828,0.0009237077,0.0001276522,0.00005270887,0.00001516328,0.00003137397,0.00001856228,0.0002591421],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1511184,"threshold_uncertainty_score":0.5588804,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006575010625864916,"score_gpt":0.2237470270044042,"score_spread":0.2171720163785393,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}