{"id":"W2953220484","doi":"10.1002/glia.23645","title":"Glial<i>HMOX1</i>expression promotes central and peripheral α‐synuclein dysregulation and pathogenicity in parkinsonian mice","year":2019,"lang":"en","type":"article","venue":"Glia","topic":"Parkinson's Disease Mechanisms and Treatments","field":"Medicine","cited_by":35,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Jewish General Hospital","funders":"Fonds de Recherche du Québec - Santé; Canadian Institutes of Health Research","keywords":"HMOX1; Biology; Substantia nigra; Cell biology; Molecular biology; Endocrinology; Internal medicine; Dopaminergic; Heme oxygenase; Dopamine; Heme; Medicine; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00019468,0.0004518946,0.0003063397,0.0004376059,0.0002312078,0.000370915,0.0002182918,0.0004003208,0.001728005],"category_scores_gemma":[0.00009251848,0.0002983561,0.0003767172,0.000170833,0.0003228653,0.0001676561,0.000214613,0.0008948297,0.000595736],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003473576,"about_ca_system_score_gemma":0.0002062499,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001350112,"about_ca_topic_score_gemma":0.002173902,"domain_scores_codex":[0.9997814,0.0000269428,0.00002373778,0.00006010687,0.00005079688,0.00005702387],"domain_scores_gemma":[0.9997035,0.00001606735,0.0001347454,0.00001906017,0.00002163501,0.0001048835],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002065475,0.00004342642,0.0003034718,0.00001860242,0.000007124588,0.000103556,0.00002052814,0.00002456756,0.998634,0.00006410851,0.00005380961,0.0005201553],"study_design_scores_gemma":[0.00006148772,0.0007146117,0.02143312,0.00002280709,0.00005360339,0.0009901017,0.0000976457,0.001091958,0.972183,0.00008609252,0.00325469,0.00001060605],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9947194,0.0006811696,0.001951227,0.0001769525,0.00003725625,0.00003572806,0.0007735345,0.0002464373,0.001378362],"genre_scores_gemma":[0.991302,0.0005926528,0.002031948,0.0001320136,0.00002036021,0.00005796225,0.0007009604,0.00011778,0.00504437],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001728005,"threshold_uncertainty_score":0.005780756,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006575010625864916,"score_gpt":0.2237470270044042,"score_spread":0.2171720163785393,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}