{"id":"W2953235672","doi":"10.1186/s13000-019-0843-z","title":"Off-label use of common predictive biomarkers in gastrointestinal malignancies: a critical appraisal","year":2019,"lang":"en","type":"review","venue":"Diagnostic Pathology","topic":"Colorectal Cancer Treatments and Studies","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"Vancouver General Hospital; University of British Columbia","funders":"","keywords":"KRAS; Medicine; Biomarker; Immunohistochemistry; Internal medicine; Oncology; Context (archaeology); Cancer; Predictive marker; ROS1; Microsatellite instability; Colorectal cancer; Pathology; Adenocarcinoma; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.04886373,0.001029383,0.004566565,0.00460134,0.0007181201,0.004668902,0.00282449,0.00365595,0.002152813],"category_scores_gemma":[0.1119646,0.0008726335,0.003574518,0.003535157,0.002352507,0.005221027,0.001741819,0.004237165,0.0008029936],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.003815241,"about_ca_system_score_gemma":0.005479612,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001457443,"about_ca_topic_score_gemma":0.002996469,"domain_scores_codex":[0.9757201,0.009405357,0.007247461,0.001541245,0.005679173,0.0004066295],"domain_scores_gemma":[0.7359093,0.1924187,0.01982389,0.004134248,0.04630787,0.001405947],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"systematic_review","study_design_scores_codex":[0.001030281,0.00005856467,0.003138724,0.08745757,0.001532454,0.000604525,0.0005463056,0.0003537502,0.0006323832,0.003900366,0.03168171,0.8690633],"study_design_scores_gemma":[0.000318447,0.001304947,0.01000996,0.3302631,0.01019495,0.004867837,0.001220413,0.0009720407,0.0014439,0.00807394,0.631104,0.0002264611],"study_design_candidate":"systematic_review","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.000521744,0.9919559,0.000559804,0.005332938,0.0008417114,0.00006465449,0.00005514235,0.00001248274,0.000655583],"genre_scores_gemma":[0.01481372,0.9684718,0.002991334,0.009616087,0.003395937,0.0002308207,0.0001691593,0.00003403087,0.0002772365],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.04886373,"threshold_uncertainty_score":0.2584192,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09265023463437293,"score_gpt":0.4000998918685375,"score_spread":0.3074496572341646,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}