{"id":"W2953246720","doi":"10.1534/genetics.116.195594","title":"Trends in DNA Methylation with Age Replicate Across Diverse Human Populations","year":2017,"lang":"en","type":"article","venue":"Genetics","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":96,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Children's Hospital; University of British Columbia","funders":"National Institute on Aging; Canadian Institutes of Health Research","keywords":"Biology; CpG site; DNA methylation; Methylation; Evolutionary biology; Genetics; Replicate; Genetic variation; Genotype; Gene; Gene expression","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002049221,0.000142364,0.000124236,0.00006235995,0.0004213762,0.0001033327,0.0002553679,0.0001429996,0.00001304146],"category_scores_gemma":[0.00003149847,0.0001378798,0.00005316425,0.00007369756,0.0001191309,0.000006156599,0.0001539973,0.00007583248,0.000004666747],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001608495,"about_ca_system_score_gemma":0.00001391732,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008936925,"about_ca_topic_score_gemma":0.004396928,"domain_scores_codex":[0.9990003,0.00003863551,0.0002111736,0.0003675026,0.0001341012,0.000248359],"domain_scores_gemma":[0.9987497,0.000003129936,0.0001822063,0.0009345622,0.00006210461,0.00006834987],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.00003002653,0.00006065373,0.166342,0.000005895695,0.00002113566,0.000009455413,0.0001957039,0.001356965,0.7983844,0.0001666642,0.00009793224,0.03332917],"study_design_scores_gemma":[0.0006753574,0.0001930071,0.7551044,0.000007524537,0.00001670197,0.00000121689,0.00004040766,0.00009685944,0.23632,0.000589103,0.006734493,0.0002209572],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9960896,0.0002422087,0.001266673,0.0001209372,0.00007957958,0.0001092178,0.00002536083,0.000009782522,0.002056654],"genre_scores_gemma":[0.9959615,0.00007749602,0.002355389,0.00002362372,0.0001489817,0.00001544334,0.000348966,0.0000251113,0.001043478],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5887625,"threshold_uncertainty_score":0.5622574,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0718573040967739,"score_gpt":0.3778016908711808,"score_spread":0.3059443867744069,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}