{"id":"W2953283118","doi":"10.3390/vaccines7020049","title":"Increased Immunogenicity of Full-Length Protein Antigens through Sortase-Mediated Coupling on the PapMV Vaccine Platform","year":2019,"lang":"en","type":"article","venue":"Vaccines","topic":"Biochemical and Structural Characterization","field":"Biochemistry, Genetics and Molecular Biology","cited_by":22,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Strong","keywords":"Immunogenicity; Antigen; Immune system; Virology; CTL*; Biology; Nucleoprotein; Virus; Chemistry; Immunology; CD8","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009510659,0.0001682286,0.000180336,0.00001721468,0.00005926675,0.00001185486,0.0001998285,0.0001497253,0.0001527575],"category_scores_gemma":[0.00009776417,0.0001041056,0.00008669653,0.0001200491,0.00001368044,0.000007308337,0.00007188813,0.0001017008,0.00001907978],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000006686204,"about_ca_system_score_gemma":0.00002403764,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004792475,"about_ca_topic_score_gemma":0.000007223475,"domain_scores_codex":[0.9991773,0.00001566659,0.000259638,0.0002501215,0.0001161292,0.0001811707],"domain_scores_gemma":[0.9993806,0.00002637284,0.000157923,0.0003053372,0.00009840878,0.0000313914],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006250659,0.00003081204,0.002878161,0.00002691148,0.00005298909,2.764329e-7,0.00001583448,0.000009027943,0.9960014,0.0000988295,0.0001269535,0.0001337623],"study_design_scores_gemma":[0.0006652888,0.0003097141,0.02255999,0.00003015788,0.00001276692,0.000003987318,0.00003336064,0.0002396693,0.9746472,0.00007537245,0.00126857,0.0001539089],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.998867,0.0001984942,0.00002654267,0.0002165144,0.00007153871,0.0004179278,0.00007604771,0.00001601176,0.0001098767],"genre_scores_gemma":[0.9987732,0.000118255,0.00006779713,0.0002065683,0.0001400064,0.0000141192,0.0005687326,0.00001656262,0.00009473358],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02135417,"threshold_uncertainty_score":0.4245303,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009348320092573678,"score_gpt":0.2147505748674794,"score_spread":0.2054022547749057,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}