{"id":"W2953283118","doi":"10.3390/vaccines7020049","title":"Increased Immunogenicity of Full-Length Protein Antigens through Sortase-Mediated Coupling on the PapMV Vaccine Platform","year":2019,"lang":"en","type":"article","venue":"Vaccines","topic":"Biochemical and Structural Characterization","field":"Biochemistry, Genetics and Molecular Biology","cited_by":22,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Strong","keywords":"Immunogenicity; Antigen; Immune system; Virology; CTL*; Biology; Nucleoprotein; Virus; Chemistry; Immunology; CD8","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001686667,0.0003120019,0.0001527806,0.0001314891,0.00007657945,0.0002180517,0.0001759971,0.00035845,0.0009739979],"category_scores_gemma":[0.0001564736,0.0001113369,0.0002379908,0.00008597064,0.0001625325,0.0002072666,0.0001818918,0.0004557682,0.0003011051],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002347362,"about_ca_system_score_gemma":0.0001341871,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002063859,"about_ca_topic_score_gemma":0.0002174774,"domain_scores_codex":[0.9999065,0.00001437776,0.000007507985,0.00002113573,0.00003194899,0.00001843198],"domain_scores_gemma":[0.9998958,0.00002594023,0.00003088205,0.00001049037,0.00001930218,0.000017569],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002219444,0.000009176499,0.00003259466,0.00001868077,0.000002277737,0.00002012411,0.000004954808,0.0000715391,0.9992419,0.00005055456,0.00001435696,0.0005116222],"study_design_scores_gemma":[0.000005532597,0.0001523077,0.0003724466,0.000001696842,0.000006848865,0.00008802361,0.000003966413,0.0008583596,0.9978151,0.00002211166,0.0006708826,0.000002538911],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9901336,0.000450553,0.008442851,0.00007150446,0.00002459607,0.00002923127,0.00008768323,0.00008185628,0.0006782624],"genre_scores_gemma":[0.9884667,0.000408033,0.009062556,0.0000508394,0.000008350051,0.00003082075,0.0001906497,0.00003023699,0.001751792],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009739979,"threshold_uncertainty_score":0.003258348,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009348320092573678,"score_gpt":0.2147505748674794,"score_spread":0.2054022547749057,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}