{"id":"W2953287427","doi":"10.1021/jacs.9b04858","title":"Nonenzymatic Template-Directed Synthesis of Mixed-Sequence 3′-NP-DNA up to 25 Nucleotides Long Inside Model Protocells","year":2019,"lang":"en","type":"article","venue":"Journal of the American Chemical Society","topic":"Origins and Evolution of Life","field":"Physics and Astronomy","cited_by":59,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Division of Chemistry; Fonds de recherche du Québec – Nature et technologies; Canadian Institutes of Health Research; Simons Foundation; Howard Hughes Medical Institute","keywords":"Protocell; Template; Chemistry; DNA; Nucleotide; Ribozyme; Oligonucleotide; Sequence (biology); RNA; Computational biology; Combinatorial chemistry; Nanotechnology; Biochemistry; Biology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002539329,0.0001651034,0.0005134311,0.00002304408,0.00005724007,0.00002476507,0.0004775783,0.00003071385,0.00008985925],"category_scores_gemma":[0.00004311133,0.0001122871,0.0005844401,0.0003293191,0.0001850081,0.0001225116,0.000118121,0.0002845867,0.00001770424],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000108566,"about_ca_system_score_gemma":0.0001527889,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00009461986,"about_ca_topic_score_gemma":3.265277e-7,"domain_scores_codex":[0.9986368,0.00004723823,0.0005379487,0.0001520615,0.0003763732,0.0002495509],"domain_scores_gemma":[0.9983203,0.0001647556,0.0009027848,0.0002811548,0.000184736,0.0001462179],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008056811,0.0002007316,0.06686348,0.00008129389,0.0003546579,4.531423e-7,0.0005731285,0.002817391,0.9055726,0.0001788084,0.02177641,0.001500502],"study_design_scores_gemma":[0.0006138273,0.0001220014,0.00725826,0.0004314522,0.0001706884,0.00001153669,0.001008493,0.016166,0.9716938,0.001078984,0.001038713,0.0004062971],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9974884,0.000006176032,0.001008389,0.0006757718,0.0001056097,0.0003107217,0.00003082413,0.00001225663,0.0003618828],"genre_scores_gemma":[0.9927525,0.000003103813,0.006699829,0.0002080848,0.0001447652,0.00001328328,5.55016e-7,0.00002032379,0.0001575715],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.06612118,"threshold_uncertainty_score":0.4578934,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01454047967178439,"score_gpt":0.2580271980544343,"score_spread":0.2434867183826499,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}