{"id":"W2953287427","doi":"10.1021/jacs.9b04858","title":"Nonenzymatic Template-Directed Synthesis of Mixed-Sequence 3′-NP-DNA up to 25 Nucleotides Long Inside Model Protocells","year":2019,"lang":"en","type":"article","venue":"Journal of the American Chemical Society","topic":"Origins and Evolution of Life","field":"Physics and Astronomy","cited_by":59,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Division of Chemistry; Fonds de recherche du Québec – Nature et technologies; Canadian Institutes of Health Research; Simons Foundation; Howard Hughes Medical Institute","keywords":"Protocell; Template; Chemistry; DNA; Nucleotide; Ribozyme; Oligonucleotide; Sequence (biology); RNA; Computational biology; Combinatorial chemistry; Nanotechnology; Biochemistry; Biology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002425191,0.0002883199,0.0002543598,0.0001009542,0.0001196295,0.0003286012,0.0003350612,0.0003254163,0.0005439459],"category_scores_gemma":[0.000374707,0.0001708793,0.0002476268,0.0001136511,0.0002571699,0.0002745211,0.0001981111,0.0005373957,0.0003933023],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002303626,"about_ca_system_score_gemma":0.0002222974,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002576711,"about_ca_topic_score_gemma":0.0005917425,"domain_scores_codex":[0.9998398,0.00002610355,0.00001232406,0.00005862599,0.00004940807,0.00001377841],"domain_scores_gemma":[0.9997846,0.0001023609,0.00004192502,0.00003319313,0.00002016678,0.00001769696],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000110764,0.000005420497,0.00005441736,0.0000369443,0.000003185561,0.00002962811,0.00001469305,0.000264997,0.9975553,0.0003426201,0.00001107166,0.001670732],"study_design_scores_gemma":[0.000001999691,0.00003683382,0.00005920454,0.000001160019,0.000003325033,0.0000373756,0.000002348099,0.0005920586,0.998422,0.00005007135,0.0007918609,0.000001754246],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8320051,0.002716426,0.1595754,0.0001327108,0.00010052,0.0001358266,0.0004075954,0.0004427478,0.004483714],"genre_scores_gemma":[0.8926994,0.001267223,0.1025787,0.00005637652,0.00001695268,0.0000960476,0.0003753422,0.00009504093,0.002814956],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0005439459,"threshold_uncertainty_score":0.00181973,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01454047967178439,"score_gpt":0.2580271980544343,"score_spread":0.2434867183826499,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}