{"id":"W2953320904","doi":"10.1002/pro.3669","title":"Optimization of peptidic HIV‐1 fusion inhibitor T20 by phage display","year":2019,"lang":"en","type":"article","venue":"Protein Science","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"National Institute of Allergy and Infectious Diseases; Canadian Institutes of Health Research; National Institutes of Health","keywords":"Gp41; Epitope; Human immunodeficiency virus (HIV); Computational biology; Sequence (biology); Peptide sequence; Enfuvirtide; Capsid; Amino acid; Biology; Genetics; Virus; Virology; Antibody","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":["insufficient_payload"],"category_scores_codex":[0.0003323576,0.00007420687,0.0001059145,0.00008436124,0.0001388751,0.00001408242,0.0002435289,0.00005118872,0.0009696831],"category_scores_gemma":[0.00007202051,0.00005478824,0.0000255827,0.000295781,0.0004094148,0.0001861065,0.0001129269,0.00008811832,0.001666606],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003952185,"about_ca_system_score_gemma":0.0001161699,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003701651,"about_ca_topic_score_gemma":0.000001145087,"domain_scores_codex":[0.9991813,0.00005272346,0.0001282156,0.0002562218,0.0001036239,0.0002779538],"domain_scores_gemma":[0.9995938,0.00002226812,0.00006303666,0.0002136155,0.00007613166,0.00003115308],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004541475,0.0001028783,0.001706938,0.00001225278,0.000005158051,7.079785e-7,0.0001027764,0.00004942934,0.995454,0.0001230041,0.0005326539,0.00186484],"study_design_scores_gemma":[0.0008525965,0.0003669159,0.0006214466,0.00004018788,0.000002908393,0.000003872496,0.00004400123,0.0001886352,0.9946601,0.00001401383,0.003130659,0.00007463888],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9943073,0.0006930258,0.001562863,0.0001751054,0.0001154144,0.0007121399,0.00005902388,0.00002220654,0.002352969],"genre_scores_gemma":[0.9929367,0.00001796306,0.0006553146,0.00001124945,0.000004904484,0.00003543712,0.00005910749,0.000004119668,0.006275217],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003922248,"threshold_uncertainty_score":0.9999436,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006672463566190609,"score_gpt":0.2447928326490016,"score_spread":0.238120369082811,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}