{"id":"W2953320904","doi":"10.1002/pro.3669","title":"Optimization of peptidic HIV‐1 fusion inhibitor T20 by phage display","year":2019,"lang":"en","type":"article","venue":"Protein Science","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"National Institute of Allergy and Infectious Diseases; Canadian Institutes of Health Research; National Institutes of Health","keywords":"Gp41; Epitope; Human immunodeficiency virus (HIV); Computational biology; Sequence (biology); Peptide sequence; Enfuvirtide; Capsid; Amino acid; Biology; Genetics; Virus; Virology; Antibody","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002046821,0.000579435,0.0004443749,0.0003297935,0.0001880096,0.000567841,0.0003707581,0.0003577235,0.0007915986],"category_scores_gemma":[0.0002636364,0.0002008747,0.0003544492,0.0004782212,0.0001741512,0.0002225163,0.0003711752,0.0004335277,0.0003536179],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003177704,"about_ca_system_score_gemma":0.0002564254,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001009602,"about_ca_topic_score_gemma":0.001259394,"domain_scores_codex":[0.9998044,0.00002555366,0.00001329345,0.0000338685,0.00006968997,0.00005311409],"domain_scores_gemma":[0.9999249,0.00001663527,0.00001655435,0.000004369253,0.00001418919,0.00002338266],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001707032,0.0001035526,0.0002422485,0.0000431936,0.00001167387,0.0001039589,0.00002284589,0.001843317,0.9928899,0.0001132287,0.00006564841,0.00438978],"study_design_scores_gemma":[0.00005784398,0.0008937861,0.001267771,0.00000723257,0.00002898559,0.0002425465,0.00003061273,0.009246192,0.9853436,0.00004924347,0.002811419,0.00002084245],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9870268,0.000945661,0.008915282,0.00005032918,0.0000140841,0.000119599,0.0002803099,0.0001525652,0.002495362],"genre_scores_gemma":[0.9848872,0.001095562,0.01147922,0.00006303697,0.000006185721,0.00009533533,0.000469417,0.00005843816,0.001845604],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001009602,"threshold_uncertainty_score":0.002648175,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006672463566190609,"score_gpt":0.2447928326490016,"score_spread":0.238120369082811,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}