{"id":"W2953332028","doi":"10.1139/v02-097","title":"Kinetic resolution of oxime esters with lipases synthesis of enantiomerically enriched building blocks with quaternary carbon centers and formal total synthesis of perhydro histrionicotoxin","year":2002,"lang":"en","type":"article","venue":"Canadian Journal of Chemistry","topic":"Enzyme Catalysis and Immobilization","field":"Biochemistry, Genetics and Molecular Biology","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Chemistry; Oxime; Kinetic resolution; Stereocenter; Lipase; Beckmann rearrangement; Stereochemistry; Enantioselective synthesis; Organic chemistry; Stereospecificity; Cyclohexanone oxime; Catalysis; Enzyme","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000340982,0.0004840543,0.0002826306,0.0001697867,0.00009631094,0.0002971732,0.0002376215,0.0002048311,0.0006603043],"category_scores_gemma":[0.0003863244,0.0001568897,0.0002518885,0.0001827619,0.0002389549,0.0003701047,0.0003551167,0.0006492442,0.0004092788],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002985513,"about_ca_system_score_gemma":0.0002193038,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002464217,"about_ca_topic_score_gemma":0.000397703,"domain_scores_codex":[0.9998537,0.00002908519,0.00002403957,0.00002076461,0.00003764922,0.00003471302],"domain_scores_gemma":[0.9998543,0.00002882679,0.00004792629,0.00002518628,0.00002348396,0.00002027257],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002903115,0.0000108319,0.00004080539,0.00002238308,0.000003590286,0.00002883728,0.00001359692,0.0002202717,0.9980247,0.0002944293,0.00001323006,0.001298345],"study_design_scores_gemma":[0.00000407282,0.00005905938,0.00005970781,0.000001409883,0.000004322329,0.00004109721,0.000004846858,0.000250507,0.9991992,0.00003288777,0.0003411936,0.000001761942],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9517459,0.001154224,0.04394761,0.0001380939,0.0000310135,0.00008280652,0.0001896525,0.0001304409,0.002580343],"genre_scores_gemma":[0.9757588,0.001317953,0.01965721,0.00003920155,0.000008590283,0.00005735894,0.0002774608,0.00005308367,0.00283031],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006603043,"threshold_uncertainty_score":0.002208948,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004782874384502441,"score_gpt":0.1763653949483092,"score_spread":0.1715825205638068,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}