{"id":"W2953357224","doi":"10.1242/jcs.213587","title":"Lysosome enlargement during inhibition of the lipid kinase PIKfyve proceeds through lysosome coalescence","year":2018,"lang":"en","type":"article","venue":"Journal of Cell Science","topic":"Calcium signaling and nucleotide metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":158,"is_retracted":false,"has_abstract":true,"ca_institutions":"Toronto Metropolitan University","funders":"National Institute of General Medical Sciences; National Institutes of Health; Natural Sciences and Engineering Research Council of Canada; Canada Research Chairs; Government of Ontario; Ryerson University","keywords":"Lysosome; Biology; Cell biology; Coalescence (physics); Biochemistry; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007142158,0.0001023061,0.0001431322,0.000065708,0.000210615,0.00003487905,0.0004475273,0.0000481036,0.00001844446],"category_scores_gemma":[0.0001319326,0.00006900969,0.0001225671,0.0003840032,0.0006969065,0.00003068215,0.0001827709,0.0001144491,0.000004177605],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002523516,"about_ca_system_score_gemma":0.000213295,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000004285627,"about_ca_topic_score_gemma":0.000001834293,"domain_scores_codex":[0.9986625,0.00003670561,0.000361681,0.0001890283,0.0005151918,0.0002348431],"domain_scores_gemma":[0.9986987,0.000006364614,0.0004554619,0.00023604,0.0005228356,0.00008060897],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000582046,0.00007734373,0.0007396397,0.00002029825,0.000004729258,0.000001745593,0.0002307509,0.00002341048,0.9985272,0.00004922499,0.0001621016,0.0001053913],"study_design_scores_gemma":[0.0004251012,0.0002918953,0.005202107,0.00007756589,0.00001946009,0.00004521012,0.000115098,0.00001766265,0.9916248,0.00008338713,0.002010701,0.00008696441],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9977643,0.0003276585,0.000406807,0.0001974168,0.0005274936,0.00007848658,0.000002079923,0.000002372346,0.0006933092],"genre_scores_gemma":[0.9980668,0.0001358217,0.0007329966,0.0001485159,0.0007320635,9.005702e-7,3.068911e-7,0.000007296161,0.0001752927],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006902312,"threshold_uncertainty_score":0.2814133,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008227354249567866,"score_gpt":0.2403700964397042,"score_spread":0.2321427421901363,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}