{"id":"W2953377481","doi":"10.1136/annrheumdis-2019-eular.2122","title":"SAT0279 MULTICENTER DOUBLE-BLIND, PROOF-OF-CONCEPT, RANDOMIZED PLACEBO-CONTROLLED TRIAL OF RIOCIGUAT IN SYSTEMIC SCLEROSIS-ASSOCIATED DIGITAL ULCERS (RESCUE)","year":2019,"lang":"en","type":"article","venue":"Annals of the Rheumatic Diseases","topic":"Systemic Sclerosis and Related Diseases","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"Bayer Canada; CSL Behring; University of Connecticut; Genentech; Acceleron; University of Michigan; Cumberland Pharmaceuticals; Pfizer","keywords":"Riociguat; Medicine; Proof of concept; Placebo; Double blind; Randomized controlled trial; Scleroderma (fungus); Internal medicine; Pulmonary hypertension; Pathology; Chronic thromboembolic pulmonary hypertension; Alternative medicine","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001614466,0.001923022,0.004046009,0.0004181967,0.0004911789,0.001321707,0.00123762,0.001624215,0.01202599],"category_scores_gemma":[0.001141759,0.0007372507,0.001735822,0.0004163488,0.001200533,0.001126404,0.0004420014,0.002874644,0.002230544],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005179541,"about_ca_system_score_gemma":0.001228561,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008464407,"about_ca_topic_score_gemma":0.002049496,"domain_scores_codex":[0.9994503,0.000248998,0.00003521359,0.0001073419,0.00005512943,0.0001029113],"domain_scores_gemma":[0.9995822,0.000108517,0.00008648319,0.00004365402,0.00004609855,0.000132937],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9817934,0.00324548,0.0001334877,0.000632839,0.0006284672,0.00002373534,0.00002043652,0.0001275561,0.003462893,0.000130421,0.0009467583,0.008854449],"study_design_scores_gemma":[0.9780239,0.0206055,0.0004533213,0.0000168783,0.0001627868,0.00001290646,0.000009725097,0.0001515546,0.0001966988,0.00004275266,0.000317346,0.000006534186],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9694549,0.00905061,0.001970463,0.001247056,0.00166686,0.005948379,0.003580289,0.0006100581,0.006471435],"genre_scores_gemma":[0.9685917,0.004675736,0.003646438,0.002720944,0.001035306,0.007622847,0.003471691,0.0001130295,0.008122349],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01202599,"threshold_uncertainty_score":0.04023093,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04173568707658423,"score_gpt":0.2919737310766453,"score_spread":0.2502380440000611,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}