{"id":"W2953385041","doi":"10.1038/s41467-019-10422-7","title":"Structural and functional consequences of the STAT5BN642H driver mutation","year":2019,"lang":"en","type":"article","venue":"Nature Communications","topic":"Immune Cell Function and Interaction","field":"Immunology and Microbiology","cited_by":84,"is_retracted":false,"has_abstract":true,"ca_institutions":"Dairy Farmers of Ontario; Structural Genomics Consortium; York University; University of Toronto","funders":"National Research Council Canada; Western Economic Diversification Canada; Österreichische Forschungsförderungsgesellschaft; Mitacs; Office of Science; Austrian Science Fund; Canadian Cancer Society Research Institute; Canada Research Chairs; Canadian Cancer Society; Government of Canada; Canada Foundation for Innovation; Ontario Research Foundation; Canadian Institutes of Health Research; Compute Canada; University of Saskatchewan; Natural Sciences and Engineering Research Council of Canada; Canadian Light Source; Argonne National Laboratory; U.S. Department of Energy","keywords":"Cancer research; Mutation; Mutant; Cell biology; Biology; Computational biology; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006178998,0.0001947138,0.00008526759,0.0001206432,0.0001345719,0.0001105799,0.0001680647,0.0003790559,0.002290255],"category_scores_gemma":[0.00007771598,0.00007579532,0.0001718382,0.0001106288,0.0001736421,0.00008383328,0.0001258771,0.0003229897,0.000272296],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003292575,"about_ca_system_score_gemma":0.0001493947,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002035947,"about_ca_topic_score_gemma":0.001889846,"domain_scores_codex":[0.9999548,0.000007096107,0.000003322918,0.000007237695,0.00001752429,0.00001002875],"domain_scores_gemma":[0.9999645,0.000006744408,0.00001003956,0.000002633221,0.000003147363,0.00001308984],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002508795,0.00004173727,0.001165535,0.00003056927,0.00001390145,0.0008282783,0.00001523224,0.001198397,0.9940289,0.0004191388,0.0002343234,0.001773198],"study_design_scores_gemma":[0.0001067149,0.0005699811,0.04191065,0.00002534804,0.00005886873,0.0045107,0.0001207456,0.02371568,0.920779,0.0008110685,0.007360108,0.00003121745],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9978236,0.000205065,0.0006408063,0.00006655505,0.00001560451,0.000006271388,0.0003856618,0.00002541211,0.0008311608],"genre_scores_gemma":[0.9989656,0.00005275541,0.0002731333,0.00002170972,0.000001598751,0.000002755458,0.0002001118,0.000006410482,0.0004760126],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002290255,"threshold_uncertainty_score":0.007661641,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01448306666714139,"score_gpt":0.2597061902730072,"score_spread":0.2452231236058658,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}