{"id":"W2953387984","doi":"10.1101/585729","title":"PFA ependymoma-associated protein EZHIP inhibits PRC2 activity through a H3 K27M-like mechanism","year":2019,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre; McGill University","funders":"National Institutes of Health; Fondation de l'Hôpital de Montréal pour enfants; Sidney Kimmel Foundation; McGill University; Greater Milwaukee Foundation; Canadian Institutes of Health Research; Genome Canada; Fonds de Recherche du Québec - Santé; Sontag Foundation","keywords":"PRC2; Histone H3; Chromatin; Biology; Gene silencing; Cell biology; Epigenetics; Methylation; Carcinogenesis; CpG site; DNA methylation; Cancer research; Genetics; DNA; Cancer; Gene expression; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008545115,0.0002643525,0.000150944,0.00008824745,0.0001233076,0.0001442728,0.0001928552,0.0001214145,0.001617766],"category_scores_gemma":[0.00009440652,0.00008722034,0.0001811683,0.00006369161,0.0001743392,0.00008768568,0.0001635531,0.0003564933,0.0004185516],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002861837,"about_ca_system_score_gemma":0.0001668105,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004312897,"about_ca_topic_score_gemma":0.0006648964,"domain_scores_codex":[0.9998995,0.00001422367,0.000009083801,0.00001843236,0.00003069513,0.00002800416],"domain_scores_gemma":[0.9999152,0.00002007441,0.00002357832,0.00001300843,0.000005403721,0.0000227513],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005238615,0.0000190809,0.0001605635,0.00001506607,0.000004548083,0.00002466216,0.000002170577,0.00005281958,0.9990453,0.0000559534,0.000029291,0.0005381334],"study_design_scores_gemma":[0.000007964164,0.0001226254,0.002247952,0.000001346304,0.000004359202,0.0001443421,0.000003754485,0.0006945563,0.995997,0.00001630591,0.0007587582,0.000001032268],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.996009,0.0006528065,0.001910991,0.00005262165,0.00001319756,0.00001272154,0.0001729659,0.00005521932,0.001120528],"genre_scores_gemma":[0.9973835,0.0001635639,0.0007341399,0.00001946314,0.000004494811,0.00001408183,0.0003009244,0.000006991473,0.001372637],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001617766,"threshold_uncertainty_score":0.005411923,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01538959030918973,"score_gpt":0.2312224932996874,"score_spread":0.2158329029904976,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}