{"id":"W2953410976","doi":"10.1158/1538-7445.am2019-ct083","title":"Abstract CT083: A Phase I/II study of aurora kinase A inhibitor, LY3295668 erbumine (AK-01): Safety as monotherapy in patients with locally advanced or metastatic solid tumors","year":2019,"lang":"en","type":"article","venue":"Cancer Research","topic":"Cancer, Hypoxia, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Jewish General Hospital; Eli Lilly (Canada); McGill University Health Centre","funders":"","keywords":"Medicine; Mucositis; Tolerability; Adverse effect; Internal medicine; Response Evaluation Criteria in Solid Tumors; Cohort; Phases of clinical research; Oncology; Gastroenterology; Surgery; Toxicity","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007489403,0.001135474,0.001082343,0.0003069718,0.0003548933,0.0006177247,0.0007219297,0.0006743184,0.005237373],"category_scores_gemma":[0.0004775198,0.0003397509,0.0006071511,0.0004438679,0.0006131729,0.0004705173,0.0002300702,0.002483953,0.001309992],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006716909,"about_ca_system_score_gemma":0.001788065,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001195763,"about_ca_topic_score_gemma":0.002748118,"domain_scores_codex":[0.9998115,0.00007528655,0.00001444806,0.00003444211,0.00002624887,0.00003813721],"domain_scores_gemma":[0.9996206,0.00004607702,0.00007051664,0.0000266002,0.00003144857,0.0002047007],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.4127226,0.06510209,0.01289417,0.001444179,0.0008469262,0.0008079631,0.000380326,0.003884527,0.3640319,0.0005338874,0.01102551,0.1263259],"study_design_scores_gemma":[0.3242123,0.6130727,0.02319648,0.00009487035,0.0005060102,0.001251573,0.0001058289,0.002343968,0.02868638,0.0001916986,0.006300637,0.00003762703],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.991509,0.002100238,0.0006456441,0.0002504555,0.00006128418,0.001662897,0.001505858,0.0001709498,0.002093741],"genre_scores_gemma":[0.9859558,0.001601175,0.001860773,0.0003830132,0.00007313708,0.001921716,0.004168591,0.00004270379,0.003993079],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005237373,"threshold_uncertainty_score":0.01752073,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02306770042322386,"score_gpt":0.3738208185280846,"score_spread":0.3507531181048607,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}