{"id":"W2953411656","doi":"10.1158/1538-7445.am2019-ct139","title":"Abstract CT139: NCI Molecular Analysis for Therapy Choice (NCI-MATCH EAY131) arm B: Phase II study of afatinib in patients (pts) with HER2 (ERBB2) activating mutations","year":2019,"lang":"en","type":"article","venue":"Cancer Research","topic":"Lung Cancer Treatments and Mutations","field":"Medicine","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"","keywords":"Medicine; Afatinib; Internal medicine; Oncology; Concomitant; Cancer; Gastroenterology; Gefitinib; Epidermal growth factor receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007841136,0.0008051413,0.001132301,0.000360827,0.0003444323,0.0006802346,0.0006773075,0.00103317,0.01463264],"category_scores_gemma":[0.0007341991,0.0002152234,0.0006841117,0.0003969712,0.0004488608,0.0005414617,0.0003091708,0.001829656,0.001394286],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001092435,"about_ca_system_score_gemma":0.001753834,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00139363,"about_ca_topic_score_gemma":0.003016816,"domain_scores_codex":[0.9997159,0.0001348642,0.00001719072,0.00005461141,0.00003208303,0.00004541803],"domain_scores_gemma":[0.9995648,0.00006901854,0.000089072,0.00002327232,0.00002387516,0.0002299495],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.8372394,0.01548937,0.007984952,0.001063257,0.0008774063,0.0003202724,0.0001166147,0.002190833,0.03782444,0.0009550258,0.0156581,0.08028032],"study_design_scores_gemma":[0.8088731,0.1635693,0.01253097,0.00008561172,0.0003359223,0.0003993882,0.00002812788,0.001977398,0.003882608,0.0005575212,0.007732063,0.00002794404],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.975298,0.002651293,0.0009010371,0.00135266,0.0001594594,0.004651127,0.005026984,0.000193665,0.009765701],"genre_scores_gemma":[0.9748948,0.001129319,0.002310929,0.001776763,0.0001854942,0.003756225,0.00592451,0.00004728245,0.009974636],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01463264,"threshold_uncertainty_score":0.04895109,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06733122609892622,"score_gpt":0.4799734623714464,"score_spread":0.4126422362725202,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}