{"id":"W2953441293","doi":"10.1093/cercor/bhz115","title":"Epigenomic Convergence of Neural-Immune Risk Factors in Neurodevelopmental Disorder Cortex","year":2019,"lang":"en","type":"article","venue":"Cerebral Cortex","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":45,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Eunice Kennedy Shriver National Institute of Child Health and Human Development; National Institute of Neurological Disorders and Stroke; National Institute of General Medical Sciences; National Institute of Mental Health; National Institute on Alcohol Abuse and Alcoholism; National Institute of Environmental Health Sciences; Canadian Institutes of Health Research; Intellectual and Developmental Disabilities Research Center; Brain and Behavior Research Foundation; University of California; University of California Berkeley; National Institutes of Health","keywords":"Epigenomics; Epigenetics; DNA methylation; Biology; Neurodevelopmental disorder; MECP2; Differentially methylated regions; Neuroscience; Genetics; Rett syndrome; Gene; Gene expression; Phenotype","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001376695,0.0001502664,0.000230421,0.001047204,0.0001545738,0.000295475,0.0001256176,0.0001301883,0.001666164],"category_scores_gemma":[0.0004833215,0.00009361743,0.0001780866,0.0006139992,0.0001606843,0.0001119465,0.0004043071,0.0001388728,0.0001212225],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002499636,"about_ca_system_score_gemma":0.0002173172,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004856076,"about_ca_topic_score_gemma":0.008665288,"domain_scores_codex":[0.9998455,0.0000253104,0.000008508748,0.00006223653,0.00003362491,0.00002488911],"domain_scores_gemma":[0.9998324,0.00004115769,0.00005753426,0.00001478404,0.00003078313,0.00002336137],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.000931203,0.0000304629,0.5728412,0.0001871447,0.0006057927,0.0006966736,0.0004763737,0.0007356179,0.3850742,0.0005710762,0.0006544359,0.0371959],"study_design_scores_gemma":[0.000003069534,0.00001937981,0.9938775,0.000005755069,0.00004045833,0.0003325444,0.00007084992,0.0002288964,0.004697566,0.0001947059,0.0005264878,0.000002857137],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9947186,0.00129592,0.001284496,0.00007945522,0.000003977727,0.000005901365,0.001629934,0.00002264586,0.0009590539],"genre_scores_gemma":[0.9972782,0.0004501148,0.0007025197,0.00003423563,0.000003710666,0.000009764562,0.0009686934,0.000009982042,0.000542955],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004856076,"threshold_uncertainty_score":0.009655654,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006628121659687063,"score_gpt":0.2236214983645471,"score_spread":0.21699337670486,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}