{"id":"W2953453625","doi":"10.1158/1538-7445.am2019-3084","title":"Abstract 3084: BI-907828: A novel, potent MDM2 inhibitor, inhibits GBM brain tumor stem cells <i>in vitro</i> and prolonged survival in orthotopic xenograft mouse models","year":2019,"lang":"en","type":"article","venue":"Cancer Research","topic":"Cancer-related Molecular Pathways","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"","keywords":"Mdm2; Temozolomide; Cancer research; Cancer; Medicine; Cell culture; Biology; Glioma; Internal medicine; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001208685,0.0006244218,0.0005289186,0.0003302786,0.0001393623,0.0002222339,0.0004232444,0.0003492474,0.001886845],"category_scores_gemma":[0.00006504168,0.0001434391,0.0002197404,0.000319523,0.0001253195,0.0001679447,0.0001423794,0.0007405487,0.001222069],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002354472,"about_ca_system_score_gemma":0.0003207019,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009746667,"about_ca_topic_score_gemma":0.001311936,"domain_scores_codex":[0.9999098,0.00001263203,0.000009574524,0.00001540535,0.00002752908,0.00002514639],"domain_scores_gemma":[0.9999675,0.000003013242,0.000006608059,0.000003406426,0.000005743848,0.00001378686],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001676366,0.000728595,0.0003223347,0.0002531823,0.00003837932,0.0001298305,0.00002095034,0.0004946183,0.9801271,0.0001295731,0.002215492,0.0138635],"study_design_scores_gemma":[0.001020471,0.00802507,0.005036498,0.00001869697,0.0001027837,0.001233479,0.0000228296,0.001721632,0.9706148,0.00005976556,0.01212353,0.00002052704],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9784557,0.008562423,0.00206381,0.0003783799,0.0001518802,0.0002670441,0.00336304,0.0006071951,0.00615056],"genre_scores_gemma":[0.9788392,0.004973926,0.003159668,0.0001926051,0.00004145144,0.0002461817,0.006573698,0.00005428818,0.005918914],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001886845,"threshold_uncertainty_score":0.006312132,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05203886776944241,"score_gpt":0.3210633849506434,"score_spread":0.269024517181201,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}