{"id":"W2953495104","doi":"10.1158/1538-7445.am2019-3114","title":"Abstract 3114: Correlation between response to atezolizumab and PD-L1 tumor expression in pediatric and young adult patients enrolled in the phase I/II iMATRIX-atezo study","year":2019,"lang":"en","type":"article","venue":"Cancer Research","topic":"Neuroblastoma Research and Treatments","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Roche (Canada)","funders":"","keywords":"Atezolizumab; Medicine; Internal medicine; Oncology; Lymphoma; Progressive disease; Cancer; Immunotherapy; Disease; Pembrolizumab","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006673179,0.0001615477,0.0003149384,0.0001573879,0.0001100513,0.0003901545,0.000160265,0.0002342562,0.001916734],"category_scores_gemma":[0.001086832,0.0001072559,0.0001854574,0.0002502543,0.000147552,0.000257243,0.0001625754,0.0003778042,0.0002534317],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002096099,"about_ca_system_score_gemma":0.0001632594,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003121402,"about_ca_topic_score_gemma":0.0005330088,"domain_scores_codex":[0.9997222,0.00008147456,0.00002643962,0.00008190397,0.00005161792,0.00003637626],"domain_scores_gemma":[0.9992449,0.0001935463,0.0003126742,0.00004559744,0.00005701898,0.0001462116],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.004906686,0.0001135048,0.9842812,0.00003350956,0.00008658708,0.00009316782,0.00004128414,0.0001748788,0.002804755,0.00003176175,0.0006355132,0.006797096],"study_design_scores_gemma":[0.000400767,0.002002461,0.99429,0.00001023219,0.00008146663,0.0004909961,0.00005224963,0.0005029502,0.0008513087,0.00002962975,0.001283096,0.000004780198],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9980939,0.000343937,0.0001075058,0.00004050235,0.000005247947,0.00001832105,0.0009029658,0.000005144151,0.0004825156],"genre_scores_gemma":[0.9981189,0.0001017308,0.0001344138,0.00004837859,0.00001493494,0.00002882966,0.001281436,0.000002512318,0.0002687465],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001916734,"threshold_uncertainty_score":0.006412148,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03379214792473315,"score_gpt":0.4051539350415538,"score_spread":0.3713617871168207,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}