{"id":"W2953508770","doi":"10.1002/etc.4531","title":"Mode of Action Classifications in the EnviroTox Database: Development and Implementation of a Consensus MOA Classification","year":2019,"lang":"en","type":"article","venue":"Environmental Toxicology and Chemistry","topic":"Computational Drug Discovery Methods","field":"Computer Science","cited_by":48,"is_retracted":false,"has_abstract":true,"ca_institutions":"Environment and Climate Change Canada","funders":"Environment and Climate Change Canada; Natural Environment Research Council; Sight Research UK; Health and Environmental Sciences Institute; U.S. Environmental Protection Agency","keywords":"Mode of action; Mode (computer interface); Computer science; Database; Biology; Toxicology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002128024,0.00006765524,0.00008940719,0.000026121,0.00003679841,0.0000067152,0.0001408238,0.00004863177,0.00003031517],"category_scores_gemma":[0.000006189788,0.00006178891,0.00001195633,0.00005872061,0.0001195504,0.00008750096,0.00008714802,0.00007965059,0.000001553995],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004397559,"about_ca_system_score_gemma":0.00003831961,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000005027529,"about_ca_topic_score_gemma":0.000004643291,"domain_scores_codex":[0.999298,0.00007789729,0.0002271141,0.0002033838,0.0001177895,0.00007582724],"domain_scores_gemma":[0.9994613,0.0001898747,0.000139253,0.0001883523,0.000002927362,0.00001829972],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.00001090756,0.000126477,0.02815217,0.00005187301,0.00001178967,6.861692e-7,0.001201273,0.0002102495,0.9545988,0.002258708,0.00001097242,0.01336603],"study_design_scores_gemma":[0.0004491586,0.00002656757,0.5366572,0.000008290438,0.000006066614,0.00002631292,0.002370834,0.0117208,0.4478727,0.000498441,0.0002803778,0.00008329917],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9950622,0.00006022564,0.004231212,0.0002504342,0.00001815906,0.0001927526,0.00001682315,0.000003673578,0.0001644816],"genre_scores_gemma":[0.9917563,0.00003738933,0.008073239,0.00003328635,0.000004368165,0.00002889244,0.00004252776,0.000002358169,0.00002160693],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.508505,"threshold_uncertainty_score":0.2519678,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02915026387392632,"score_gpt":0.3204837890398717,"score_spread":0.2913335251659454,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}