{"id":"W2953511998","doi":"10.1200/po.18.00266","title":"Efficacy of Vemurafenib in Patients With Non–Small-Cell Lung Cancer With <i>BRAF</i> V600 Mutation: An Open-Label, Single-Arm Cohort of the Histology-Independent VE-BASKET Study","year":2019,"lang":"en","type":"article","venue":"JCO Precision Oncology","topic":"Melanoma and MAPK Pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":66,"is_retracted":false,"has_abstract":true,"ca_institutions":"Roche (Canada)","funders":"National Cancer Institute","keywords":"Medicine; Vemurafenib; Internal medicine; Cohort; Lung cancer; Clinical endpoint; Oncology; Adverse effect; Progression-free survival; Cancer; Surgery; Clinical trial; Overall survival; Metastatic melanoma","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003638391,0.000220389,0.0004994438,0.00007473258,0.00005001831,0.00001134979,0.0007064227,0.0002391952,0.00005635447],"category_scores_gemma":[0.00002908514,0.0001449711,0.00002821919,0.0001846681,0.0001047093,0.00001167035,0.0003565444,0.0001803555,0.000002648145],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001031156,"about_ca_system_score_gemma":0.000480701,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001580147,"about_ca_topic_score_gemma":0.001923225,"domain_scores_codex":[0.998101,0.0003216501,0.0004487523,0.0005872747,0.000288001,0.0002533239],"domain_scores_gemma":[0.9983177,0.00007940884,0.0004947725,0.0007668611,0.0002663815,0.00007489816],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00502763,0.01035325,0.8721364,0.00004017642,0.0001150966,0.00001174001,0.0005969825,0.000366317,0.1051903,0.000006275466,0.0001354479,0.006020411],"study_design_scores_gemma":[0.03143924,0.04188529,0.8540794,0.00009945319,0.0001801917,0.00001177153,0.0002491673,0.00005968809,0.07049302,0.000004930981,0.00116431,0.0003335894],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9947349,0.00007666886,0.00005069113,0.000033312,0.0003509666,0.00289872,0.00002453969,0.00000501645,0.001825207],"genre_scores_gemma":[0.9986949,0.000008892235,0.000488482,0.0001281537,0.0000313456,0.0001358738,0.00006854312,0.00003065923,0.0004131323],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03469726,"threshold_uncertainty_score":0.5911751,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01430066329293688,"score_gpt":0.2775151109011461,"score_spread":0.2632144476082092,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}