{"id":"W2953511998","doi":"10.1200/po.18.00266","title":"Efficacy of Vemurafenib in Patients With Non–Small-Cell Lung Cancer With <i>BRAF</i> V600 Mutation: An Open-Label, Single-Arm Cohort of the Histology-Independent VE-BASKET Study","year":2019,"lang":"en","type":"article","venue":"JCO Precision Oncology","topic":"Melanoma and MAPK Pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":66,"is_retracted":false,"has_abstract":true,"ca_institutions":"Roche (Canada)","funders":"National Cancer Institute","keywords":"Medicine; Vemurafenib; Internal medicine; Cohort; Lung cancer; Clinical endpoint; Oncology; Adverse effect; Progression-free survival; Cancer; Surgery; Clinical trial; Overall survival; Metastatic melanoma","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002538184,0.001558192,0.002914803,0.0003305874,0.0004658541,0.001185481,0.0006749228,0.0008793737,0.001080142],"category_scores_gemma":[0.001629779,0.0005619148,0.001636338,0.0002907559,0.0008290364,0.001158664,0.0005323995,0.001932544,0.000335213],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006157458,"about_ca_system_score_gemma":0.0008525419,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004408722,"about_ca_topic_score_gemma":0.0009274358,"domain_scores_codex":[0.9990085,0.0004311106,0.00007475265,0.0001996825,0.0001192827,0.000166646],"domain_scores_gemma":[0.9985141,0.0002300829,0.0003221113,0.0001953612,0.000117079,0.0006211895],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.754702,0.02464437,0.1244163,0.0003774225,0.002457072,0.0007595526,0.0003986525,0.002057444,0.03923932,0.0001890562,0.001973713,0.0487851],"study_design_scores_gemma":[0.342779,0.3901546,0.2480154,0.00005470715,0.002103518,0.001310866,0.0002930133,0.003916101,0.007865633,0.0004296734,0.00291423,0.0001631901],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9985219,0.0004049172,0.0001451108,0.00004556979,0.00002477055,0.0003129856,0.000324284,0.00001051652,0.000210139],"genre_scores_gemma":[0.9974532,0.0002628389,0.0002837612,0.0001555312,0.00008922601,0.0003409207,0.00112666,0.000006835394,0.0002810923],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002914803,"threshold_uncertainty_score":0.01342338,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01430066329293688,"score_gpt":0.2775151109011461,"score_spread":0.2632144476082092,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}