{"id":"W2953513002","doi":"10.1111/gtc.12710","title":"Specific basic patch‐dependent multimerization of <i>Saccharomyces cerevisiae</i> ORC on single‐stranded DNA promotes ATP hydrolysis","year":2019,"lang":"en","type":"article","venue":"Genes to Cells","topic":"DNA Repair Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Japan Society for the Promotion of Science; Ministry of Education, Culture, Sports, Science and Technology; Shinnihon Foundation of Advanced Medical Treatment Research; Institute of Genetics; Naito Foundation","keywords":"Biology; Helicase; Saccharomyces cerevisiae; DNA; DNA replication; Cell biology; Origin recognition complex; ATP hydrolysis; Origin of replication; Genetics; Yeast; Biochemistry; ATPase; Eukaryotic DNA replication; Gene; Enzyme; RNA","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001148805,0.0002739169,0.0001448763,0.00009665955,0.00008413224,0.0002263463,0.0001330183,0.0001052517,0.001082104],"category_scores_gemma":[0.0001160211,0.0001268086,0.0001505641,0.00007081786,0.0001410939,0.0001374416,0.0002133212,0.0002229748,0.000388881],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002493599,"about_ca_system_score_gemma":0.0001098798,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000538043,"about_ca_topic_score_gemma":0.001039307,"domain_scores_codex":[0.9999267,0.000009372978,0.000005859858,0.00002490961,0.00001695181,0.00001628446],"domain_scores_gemma":[0.9999121,0.00001392626,0.00002505847,0.00001512033,0.000008222279,0.00002549859],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003231597,0.000006689727,0.0001460092,0.00001546241,0.000002146878,0.00001242562,0.000004395489,0.00002271187,0.9991503,0.00004323228,0.00002552829,0.0005388214],"study_design_scores_gemma":[0.000008819257,0.00007195325,0.004469668,0.000003074789,0.000008860929,0.0001125765,0.00001358463,0.0009138418,0.9926967,0.00003343588,0.001663853,0.000003553237],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9957746,0.0007826175,0.001882581,0.00004334108,0.00001853568,0.0000139779,0.0001327681,0.000125106,0.001226422],"genre_scores_gemma":[0.9972563,0.0002275224,0.00109964,0.00002502633,0.000006599584,0.000007958917,0.0002114322,0.00002283734,0.001142736],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001082104,"threshold_uncertainty_score":0.003619969,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008986701290672769,"score_gpt":0.2061019159912007,"score_spread":0.1971152147005279,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}