{"id":"W2953541197","doi":"10.1158/1538-7445.am2019-ct012","title":"Abstract CT012: Open-label, multicenter, Phase Ib study to assess safety, tolerability and efficacy of adavosertib monotherapy in patients with advanced solid tumors: Expansion cohorts","year":2019,"lang":"en","type":"article","venue":"Cancer Research","topic":"Advanced Breast Cancer Therapies","field":"Medicine","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"Spinal Cord Injury BC; Princess Margaret Cancer Centre; University of Alberta","funders":"","keywords":"Medicine; Tolerability; Nausea; Internal medicine; Adverse effect; Response Evaluation Criteria in Solid Tumors; Oncology; Breast cancer; Cancer; Metastatic breast cancer; Gastroenterology; Progressive disease; Chemotherapy; Surgery","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009829456,0.0002768861,0.0008959692,0.0002857064,0.00008985004,0.00004540353,0.0003902327,0.0000565396,0.0002565042],"category_scores_gemma":[0.0001285249,0.0002204283,0.00002348733,0.0006561098,0.0001680112,0.0004338834,0.0002792318,0.0005213561,0.000008700663],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006110028,"about_ca_system_score_gemma":0.0004130406,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009175304,"about_ca_topic_score_gemma":0.0005180755,"domain_scores_codex":[0.9966327,0.0002122776,0.0006317215,0.0008548936,0.001039447,0.0006289494],"domain_scores_gemma":[0.997643,0.0002926026,0.0001556693,0.0008725238,0.0007247492,0.000311447],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.1230488,0.01532639,0.6209832,0.0002744621,0.0001342781,0.00002433116,0.003108423,0.0003862887,0.057865,0.000002973438,0.000009629161,0.1788363],"study_design_scores_gemma":[0.08103849,0.01049157,0.89339,0.001322541,0.00001424227,8.737335e-7,0.001260662,0.00004051539,0.01198398,0.00001061272,0.000208781,0.0002377466],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9902971,0.0003805483,0.00002637894,0.0002239375,0.00008256066,0.008845096,0.00004983468,0.00002440098,0.00007010332],"genre_scores_gemma":[0.9987267,0.0000809947,0.0004665906,0.0001123076,0.00003445196,0.0004143757,0.00001905883,0.00006970496,0.00007584873],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2724068,"threshold_uncertainty_score":0.8988805,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08270640598563027,"score_gpt":0.4678702122921664,"score_spread":0.3851638063065361,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}