{"id":"W2953571606","doi":"10.1016/j.bbi.2019.07.001","title":"Brain eicosapentaenoic acid metabolism as a lead for novel therapeutics in major depression","year":2019,"lang":"en","type":"review","venue":"Brain Behavior and Immunity","topic":"Tryptophan and brain disorders","field":"Neuroscience","cited_by":78,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto","funders":"National Center for Complementary and Integrative Health; Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"Eicosapentaenoic acid; Depression (economics); Microglia; Blood–brain barrier; Neuroscience; Metabolism; Pharmacology; Medicine; Biology; Central nervous system; Internal medicine; Inflammation; Biochemistry; Fatty acid; Polyunsaturated fatty acid","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005018378,0.0008581316,0.001640709,0.001213869,0.0001871855,0.0009328951,0.0006899097,0.001097808,0.003603432],"category_scores_gemma":[0.0005699706,0.0002262947,0.0004011772,0.001262042,0.0003870783,0.000939857,0.0005816616,0.001973504,0.00174012],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005203268,"about_ca_system_score_gemma":0.0007836269,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009078649,"about_ca_topic_score_gemma":0.002507731,"domain_scores_codex":[0.9999106,0.00001804872,0.00001449415,0.00001752348,0.00002700401,0.00001222045],"domain_scores_gemma":[0.9998116,0.000092074,0.00002547564,0.00000535344,0.00004471595,0.00002075487],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002427694,0.000121857,0.0001314015,0.01409971,0.0001618619,0.0002446971,0.00003727854,0.000468458,0.001917981,0.00330314,0.02987478,0.9493961],"study_design_scores_gemma":[0.0001777882,0.0003763058,0.001262283,0.005651868,0.0005234653,0.001474438,0.00007903838,0.0003670643,0.000717404,0.004761032,0.984576,0.00003330178],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0000846489,0.9989472,0.00008903046,0.0002037885,0.0001535559,0.00000316293,0.00001360382,0.000004892325,0.0005000998],"genre_scores_gemma":[0.000857792,0.9980134,0.000180999,0.0002289714,0.0002203011,0.000005760266,0.00002583543,0.00000121738,0.000465756],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.003603432,"threshold_uncertainty_score":0.01205468,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1255083299920636,"score_gpt":0.3818053615930097,"score_spread":0.256297031600946,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}