{"id":"W2953589658","doi":"10.1007/s40258-019-00489-0","title":"Cost Effectiveness of the Third-Generation Tyrosine Kinase Inhibitor (TKI) Ponatinib, vs. Second-Generation TKIs or Stem Cell Transplant, as Third-Line Treatment for Chronic-Phase Chronic Myeloid Leukemia","year":2019,"lang":"en","type":"article","venue":"Applied Health Economics and Health Policy","topic":"Chronic Myeloid Leukemia Treatments","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":false,"ca_institutions":"Princess Margaret Cancer Centre","funders":"Incyte; Ariad Pharmaceuticals","keywords":"Ponatinib; Medicine; Myeloid leukemia; Dasatinib; Tyrosine-kinase inhibitor; Tyrosine kinase; Health economics; Stem cell; Quality of Life Research; Internal medicine; Imatinib; Cancer research; Oncology; Public health; Cancer; Biology; Receptor; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002545223,0.0005301476,0.001248388,0.0006746816,0.000215316,0.001636788,0.0006758683,0.001630986,0.009147381],"category_scores_gemma":[0.01046573,0.0002888096,0.003061415,0.0008467101,0.0004891201,0.001396126,0.000706135,0.001740555,0.000207354],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.004601408,"about_ca_system_score_gemma":0.002962174,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.01241975,"about_ca_topic_score_gemma":0.00784873,"domain_scores_codex":[0.9978604,0.001383989,0.00008657596,0.0001106601,0.0001712542,0.0003870364],"domain_scores_gemma":[0.995559,0.003242653,0.0005553729,0.00007937377,0.000173681,0.0003899707],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"simulation_or_modeling","study_design_gemma":"observational","study_design_scores_codex":[0.2359788,0.005271313,0.03730733,0.003102793,0.007447242,0.0005371846,0.00019202,0.3981501,0.002043636,0.03305318,0.01511217,0.2618041],"study_design_scores_gemma":[0.06583596,0.05228513,0.2403592,0.002180601,0.02808116,0.001857031,0.002394018,0.5141784,0.005167276,0.06205497,0.025225,0.0003812115],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9486583,0.0205965,0.001804685,0.00999938,0.0006031767,0.0003064205,0.003076308,0.00007596774,0.01487914],"genre_scores_gemma":[0.9967783,0.001402235,0.000263515,0.0004399581,0.00006484798,0.00003382052,0.0002912028,0.000005620038,0.0007205111],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01241975,"threshold_uncertainty_score":0.03338569,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06399726909779262,"score_gpt":0.3576796119660173,"score_spread":0.2936823428682247,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}