{"id":"W2953594239","doi":"10.1002/acn3.50827","title":"Key inflammatory pathway activations in the MCI stage of Alzheimer’s disease","year":2019,"lang":"en","type":"article","venue":"Annals of Clinical and Translational Neurology","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":46,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute on Aging; National Institute of Biomedical Imaging and Bioengineering; Canadian Institutes of Health Research; Genentech; National Institutes of Health; H. Lundbeck A/S; Servier; Fujirebio Europe; Eisai; Northern California Institute for Research and Education; Pfizer; Biogen; BioClinica; F. Hoffmann-La Roche; IXICO; Takeda Pharmaceutical Company; Bristol-Myers Squibb; Cleveland Clinic; AbbVie; Health Research; University of Southern California; Roche; Elan; Novartis; Novartis Pharmaceuticals Corporation; U.S. Department of Defense; Eli Lilly and Company; Merck; Alzheimer's Association; Foundation for the National Institutes of Health; GE Healthcare; Alzheimer's Disease Neuroimaging Initiative; Johnson and Johnson; Meso Scale Diagnostics","keywords":"KEGG; Medicine; Transcriptome; Alzheimer's Disease Neuroimaging Initiative; Biomarker; Proinflammatory cytokine; Neurodegeneration; Bioinformatics; Disease; Pathology; Immunology; Inflammation; Alzheimer's disease; Gene; Biology; Gene expression; Genetics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003990745,0.00007899498,0.0002869185,0.00007388781,0.00001993762,0.000002212274,0.00006277065,0.00006867942,0.0001364817],"category_scores_gemma":[0.0001106496,0.00005228093,0.0001510194,0.00009309602,0.0002220347,0.0000700415,0.00001208016,0.0002031298,0.00001021043],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":9.923507e-8,"about_ca_system_score_gemma":0.0002159058,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001244873,"about_ca_topic_score_gemma":0.000006405676,"domain_scores_codex":[0.9986762,0.0002295639,0.0005090935,0.0001799201,0.0002676651,0.0001374975],"domain_scores_gemma":[0.9985682,0.0009042117,0.000105861,0.0001774953,0.00009940875,0.0001448556],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.002331012,0.0008328191,0.9873244,0.00004871066,0.0006279389,0.00004364824,0.00004820881,0.00002783619,0.0000116301,0.006770096,0.00003724209,0.001896486],"study_design_scores_gemma":[0.001700103,0.0004462578,0.9933333,0.00001391296,0.00007162244,0.000002028195,0.000006906135,0.0002398509,0.00005965277,0.002606301,0.001483561,0.00003644021],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9828576,0.001557497,0.000003441197,0.01424311,0.00002897474,0.0003879237,0.0001159642,0.000004487425,0.0008009573],"genre_scores_gemma":[0.9981037,0.0003312657,0.00001593381,0.001429966,0.0000329696,0.00001242826,0.00004937649,0.000005969721,0.00001840138],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01524604,"threshold_uncertainty_score":0.2131954,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.161310321885492,"score_gpt":0.4292174700870217,"score_spread":0.2679071482015297,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}