{"id":"W2953653332","doi":"10.1158/1538-7445.am2019-2720","title":"Abstract 2720: Mitochondrial ClpP-mediated proteolysis induces selective cancer cell lethality","year":2019,"lang":"en","type":"article","venue":"Cancer Research","topic":"Ubiquitin and proteasome pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University Health Network","funders":"","keywords":"Protease; Proteolysis; In vivo; In vitro; Cancer cell; Biology; Synthetic lethality; Cancer; Mutant; Programmed cell death; Apoptosis; Cell biology; Cancer research; Biochemistry; Chemistry; Enzyme; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000127766,0.0004686737,0.000361339,0.000297479,0.0001658994,0.0002890677,0.0002636653,0.0003838245,0.004133265],"category_scores_gemma":[0.0001153195,0.0001147257,0.0003328187,0.0002235525,0.0001950661,0.0001106709,0.0002420864,0.0008385023,0.0009116391],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003159537,"about_ca_system_score_gemma":0.0002662437,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006174854,"about_ca_topic_score_gemma":0.0005722877,"domain_scores_codex":[0.9997821,0.00003638774,0.00002237493,0.0000331487,0.00006800037,0.00005783243],"domain_scores_gemma":[0.9998466,0.00004094472,0.00003094982,0.00002550392,0.00001524472,0.00004066237],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002662163,0.0001169184,0.0001258805,0.00004222115,0.000008280746,0.0002216496,0.00000926043,0.0001235693,0.997178,0.0002033019,0.000350128,0.001354491],"study_design_scores_gemma":[0.00005637584,0.0007817072,0.002328165,0.000005085249,0.00001039246,0.0005911804,0.00001774852,0.001165868,0.9920746,0.00006673073,0.00289799,0.00000415255],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9831336,0.001655632,0.003759031,0.0003356528,0.0001138366,0.00009701166,0.002932741,0.0003117914,0.007660664],"genre_scores_gemma":[0.9905394,0.0006439654,0.001126588,0.0001242875,0.00001870685,0.00006504607,0.002655771,0.00004712288,0.004779087],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004133265,"threshold_uncertainty_score":0.01382709,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04644365813195454,"score_gpt":0.3630070374939595,"score_spread":0.316563379362005,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}