{"id":"W2953671548","doi":"10.4049/jimmunol.1801472","title":"LILRB1 Blockade Enhances Bispecific T Cell Engager Antibody–Induced Tumor Cell Killing by Effector CD8+ T Cells","year":2019,"lang":"en","type":"article","venue":"The Journal of Immunology","topic":"Immune Cell Function and Interaction","field":"Immunology and Microbiology","cited_by":46,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"U.S. Food and Drug Administration; Amgen","keywords":"Effector; Blockade; Cytotoxic T cell; Bispecific antibody; T cell; CD8; Antibody; Cell biology; Cancer research; Cell; Chemistry; Molecular biology; Biology; Antigen; Immunology; Biochemistry; Receptor; Monoclonal antibody; Immune system","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":["insufficient_payload"],"category_scores_codex":[0.001041051,0.000329217,0.000607351,0.000255504,0.0003030439,0.00003111969,0.0006784984,0.0003175112,0.004407328],"category_scores_gemma":[0.0000444969,0.0002224164,0.0002803274,0.0001932145,0.0001751675,0.0002416869,0.0001048452,0.001853137,0.00567795],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008976409,"about_ca_system_score_gemma":0.00008925972,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007680518,"about_ca_topic_score_gemma":0.000001363695,"domain_scores_codex":[0.9970357,0.001268241,0.0008400523,0.0002326651,0.0000860751,0.0005372699],"domain_scores_gemma":[0.9973489,0.000892397,0.001050568,0.0004643557,0.0002163848,0.00002739297],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0009747434,0.0002664273,0.0001161325,0.00002351119,0.0002239642,0.000005796019,0.0006534004,0.00001911712,0.9864486,0.000005430151,0.01094556,0.0003172673],"study_design_scores_gemma":[0.001898308,0.001315241,0.0003134342,0.00005317324,0.0001005604,0.000295722,0.001217037,0.000007595426,0.8965564,0.000006430286,0.09801689,0.0002191831],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9669828,0.01353369,0.0003101572,0.000217176,0.01624569,0.0002647552,0.000003527845,0.00003513722,0.002407026],"genre_scores_gemma":[0.9822332,0.002106089,0.00002409933,0.0002390596,0.0001268358,0.000002821826,0.00002493261,0.00004037585,0.01520263],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.08989222,"threshold_uncertainty_score":0.9965028,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00693551193680826,"score_gpt":0.2221695433535521,"score_spread":0.2152340314167438,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}