{"id":"W2953671780","doi":"10.1172/jci125538","title":"Ankyrin-B dysfunction predisposes to arrhythmogenic cardiomyopathy and is amenable to therapy","year":2019,"lang":"en","type":"article","venue":"Journal of Clinical Investigation","topic":"Cardiovascular Effects of Exercise","field":"Medicine","cited_by":57,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University; Population Health Research Institute; Hospital for Sick Children; University of British Columbia; Dalhousie University; Toronto General Hospital; University of Toronto; Western University","funders":"National Center for Advancing Translational Sciences; National Human Genome Research Institute; National Heart, Lung, and Blood Institute; National Institutes of Health; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; ZonMw; Fondation Leducq; Johns Hopkins University; Canadian Institutes of Health Research; Ohio State University","keywords":"Wnt signaling pathway; Cardiomyopathy; Ankyrin; Sudden cardiac death; Plakoglobin; Phenotype; Medicine; Ankyrin repeat; Sudden death; Catenin; Cancer research; Heart failure; Internal medicine; Biology; Cell biology; Signal transduction; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002444885,0.0001452075,0.0008039427,0.0002129254,0.00003073847,0.00004278852,0.00007314501,0.0001400308,0.00005018882],"category_scores_gemma":[0.001320799,0.0001139757,0.0004872549,0.0002908449,0.00005172312,0.0002295101,0.00004002526,0.0003279244,0.0001030392],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005665148,"about_ca_system_score_gemma":0.0001862289,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001660183,"about_ca_topic_score_gemma":0.000001057247,"domain_scores_codex":[0.9979145,0.0001712056,0.0009082967,0.0002620766,0.0005717226,0.0001722047],"domain_scores_gemma":[0.9979773,0.0002657918,0.0003072853,0.0003520117,0.000452566,0.0006450615],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.007331854,0.0003249,0.631629,0.0002899143,0.00152821,0.0001823108,0.001353261,0.001299276,0.0800095,0.00007738688,0.03296261,0.2430117],"study_design_scores_gemma":[0.0058444,0.006875199,0.9351014,0.0006804388,0.0004052754,0.0005253433,0.0001057776,0.0002385032,0.01850208,0.000568741,0.03091879,0.0002340797],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9928476,0.0007769306,0.0004524935,0.003728011,0.001073578,0.0007845653,0.000002528017,0.00001790338,0.0003164443],"genre_scores_gemma":[0.9890549,0.0004167398,0.003670434,0.005020497,0.00143491,0.000007798916,0.000002741942,0.00002599995,0.0003660148],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3034723,"threshold_uncertainty_score":0.4647795,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03772923377244257,"score_gpt":0.3416868653558006,"score_spread":0.303957631583358,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}