{"id":"W2953701154","doi":"10.1002/hep.30839","title":"Type 3 Inositol 1,4,5‐Trisphosphate Receptor Is Increased and Enhances Malignant Properties in Cholangiocarcinoma","year":2019,"lang":"en","type":"article","venue":"Hepatology","topic":"Drug Transport and Resistance Mechanisms","field":"Medicine","cited_by":74,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Cancer Research; University of Calgary","funders":"National Center for Advancing Translational Sciences; National Institute of Diabetes and Digestive and Kidney Diseases; National Cancer Institute; National Institutes of Health","keywords":"Endoplasmic reticulum; Inositol trisphosphate receptor; Biology; Cell biology; Mitochondrion; Inositol; Calcium signaling; Cancer research; Receptor; Signal transduction; Pathology; Medicine; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001047389,0.0001381614,0.0003891386,0.0001026338,0.00002625093,0.000007235353,0.00006123347,0.0001426001,0.0004121762],"category_scores_gemma":[0.00001112505,0.000100366,0.00003831929,0.0001588001,0.00006346077,0.00005554998,0.00001810663,0.0001357942,0.0001925791],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002631869,"about_ca_system_score_gemma":0.00009304811,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000296938,"about_ca_topic_score_gemma":0.00009207457,"domain_scores_codex":[0.9990774,0.00003199769,0.0002195826,0.0002922264,0.0001119289,0.0002668441],"domain_scores_gemma":[0.9996164,0.00001542315,0.00004708106,0.0001883958,0.0000488802,0.00008374683],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000648606,0.00007652281,0.8775178,0.0002166868,0.00002544711,0.0000856656,0.0004787113,3.175102e-8,0.119889,0.0002682164,0.0002811091,0.0005121906],"study_design_scores_gemma":[0.003430256,0.000661895,0.260139,0.0004254627,0.0000761786,0.0001221232,0.0004092965,0.0003337604,0.7096297,0.0001408022,0.02428032,0.00035127],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9935912,0.003883615,0.000003521171,0.0008404964,0.0003484081,0.0004003795,0.000003729205,0.00003759569,0.0008910043],"genre_scores_gemma":[0.9964498,0.0006094666,0.0002898685,0.0008021377,0.00002942025,0.00001875301,0.00001450194,0.00001740708,0.001768705],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6173788,"threshold_uncertainty_score":0.451304,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01262410771307823,"score_gpt":0.226829507495469,"score_spread":0.2142053997823907,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}