{"id":"W2953726607","doi":"10.1158/1538-7445.am2019-3829","title":"Abstract 3829: NEO1132 and NEO2734, novel dual bromodomain inhibitors of both BET and CREBBP/EP300, compared to single BET or CREBB/EP300 inhibitors in diffuse large B cell lymphoma","year":2019,"lang":"en","type":"article","venue":"Cancer Research","topic":"Protein Degradation and Inhibitors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Aegera Therapeutics (Canada)","funders":"","keywords":"Bromodomain; Diffuse large B-cell lymphoma; Lymphoma; Cancer research; CREB-binding protein; BET inhibitor; BRD4; Chromosomal translocation; Transcription factor; Biology; Chemistry; Molecular biology; Acetylation; CREB; Biochemistry; Immunology; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009209518,0.0003993359,0.0004690961,0.0002580679,0.0001002175,0.0002104558,0.0003140389,0.0003217079,0.003325347],"category_scores_gemma":[0.00008456812,0.000155897,0.000268347,0.0002106467,0.0001510706,0.0002048217,0.0001827346,0.0007345302,0.000544171],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001978451,"about_ca_system_score_gemma":0.0002646395,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008539505,"about_ca_topic_score_gemma":0.001583445,"domain_scores_codex":[0.9999253,0.00001380008,0.000005142701,0.00001248089,0.00002315172,0.00002019547],"domain_scores_gemma":[0.9999532,0.000007980805,0.000007473216,0.00000369968,0.000006552797,0.00002112902],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.003221227,0.0008183271,0.0003344249,0.000250601,0.00004362757,0.0001343099,0.00002806107,0.0004952882,0.9797229,0.0002128657,0.0007813072,0.01395706],"study_design_scores_gemma":[0.001235405,0.01240874,0.008891166,0.00002637939,0.0001085008,0.0007945734,0.00005540946,0.001892215,0.9664626,0.00009997693,0.008004655,0.00002037883],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9876618,0.005426032,0.0008744695,0.000203631,0.00007069426,0.000107461,0.0009080773,0.00009225072,0.004655659],"genre_scores_gemma":[0.9878938,0.003176307,0.0009354941,0.0001150246,0.00001729036,0.00008667164,0.001515156,0.00001857483,0.006241733],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003325347,"threshold_uncertainty_score":0.01112437,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03661806156576262,"score_gpt":0.3262900807861814,"score_spread":0.2896720192204187,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}