{"id":"W2953737360","doi":"10.1158/1538-7445.am2019-5225","title":"Abstract 5225: Androgen deprivation upregulates SPINK1 expression and potentiates cellular plasticity in prostate cancer","year":2019,"lang":"en","type":"article","venue":"Cancer Research","topic":"Prostate Cancer Treatment and Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"","keywords":"Prostate cancer; LNCaP; Androgen receptor; Androgen deprivation therapy; Cancer research; P-Chloroamphetamine; Gene knockdown; Corepressor; SOX2; Transcription factor; Biology; Downregulation and upregulation; Endocrinology; Gene silencing; Prostate; Cancer; Medicine; Internal medicine; Repressor; Receptor; Cell culture; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00005209768,0.0002186661,0.0002465599,0.0002038687,0.0001938553,0.0002856715,0.0001323494,0.0001374536,0.003667149],"category_scores_gemma":[0.00004853638,0.00008115416,0.0002266847,0.0001711893,0.0001590505,0.0001025741,0.0002076414,0.0004965118,0.0006055572],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002086198,"about_ca_system_score_gemma":0.0002116943,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009557456,"about_ca_topic_score_gemma":0.002105897,"domain_scores_codex":[0.9999106,0.00001019931,0.000007286073,0.00001693693,0.00002691867,0.00002807632],"domain_scores_gemma":[0.9999624,0.000004218088,0.000007057255,0.000004405472,0.000003540771,0.00001826079],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002143704,0.00005043532,0.0003877087,0.00007742178,0.000008483585,0.0000744252,0.00001166944,0.00004293214,0.9960904,0.00006357497,0.0003258829,0.002652842],"study_design_scores_gemma":[0.00007378634,0.001706825,0.05299421,0.00002073159,0.00005066422,0.0006214817,0.000105142,0.0007469467,0.9310859,0.0001055425,0.01246864,0.00002013845],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.987955,0.005806361,0.0007959245,0.0002531905,0.0001275868,0.00002983679,0.00136753,0.000177821,0.003486848],"genre_scores_gemma":[0.9922534,0.001318364,0.0003699438,0.00009751161,0.00002158537,0.00002611367,0.001008303,0.00001536922,0.00488945],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003667149,"threshold_uncertainty_score":0.01226783,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04397012191042377,"score_gpt":0.3695935053490898,"score_spread":0.325623383438666,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}