{"id":"W2953738181","doi":"10.1016/j.heares.2019.07.003","title":"Early phase trials of novel hearing therapeutics: Avenues and opportunities","year":2019,"lang":"en","type":"review","venue":"Hearing Research","topic":"Hearing, Cochlea, Tinnitus, Genetics","field":"Neuroscience","cited_by":21,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia","funders":"UCLH Biomedical Research Centre; Collaboration for Leadership in Applied Health Research and Care - Greater Manchester; National Institute for Health and Care Research","keywords":"Clinical trial; Stakeholder; Health care; Medicine; Stakeholder engagement; Key (lock); Hearing loss; Business; Intensive care medicine; Computer science; Public relations; Political science; Audiology; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.01080903,0.000531056,0.002956161,0.001288421,0.0003426067,0.0004352191,0.0009566229,0.0005145089,0.00006792352],"category_scores_gemma":[0.004710865,0.00047496,0.0004528047,0.0007004677,0.0007571123,0.0001711671,0.001181237,0.002033538,0.0001163969],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000162219,"about_ca_system_score_gemma":0.001304562,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002084485,"about_ca_topic_score_gemma":0.000002736223,"domain_scores_codex":[0.9915075,0.002641115,0.001810058,0.00113088,0.001687954,0.001222452],"domain_scores_gemma":[0.9906797,0.006789571,0.0005984273,0.001322187,0.0002873148,0.0003227647],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00004954019,0.0002761389,0.00001252181,0.01776958,0.00007812317,0.00004128625,0.0007362509,0.000001528039,0.006366117,0.001038089,0.00009023483,0.9735406],"study_design_scores_gemma":[0.001061711,0.0005020026,0.0000184759,0.01192262,0.0001932056,0.00008814723,0.00007649433,0.0001238514,0.001896081,0.00008685215,0.9835547,0.0004758683],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.008607069,0.9862357,0.00005292745,0.00008754378,0.0003579694,0.002230955,0.000180611,0.00008086195,0.002166404],"genre_scores_gemma":[0.002689746,0.9932916,0.0002806503,0.00005209259,0.000332031,0.00009788822,0.000009562142,0.0001833779,0.003063076],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9834645,"threshold_uncertainty_score":0.9997702,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.9074678628389411,"score_gpt":0.5989026959052519,"score_spread":0.3085651669336892,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}