{"id":"W2953750178","doi":"10.1186/s13195-019-0512-1","title":"FDG-PET as an independent biomarker for Alzheimer’s biological diagnosis: a longitudinal study","year":2019,"lang":"en","type":"article","venue":"Alzheimer s Research & Therapy","topic":"Dementia and Cognitive Impairment Research","field":"Medicine","cited_by":161,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute on Aging; National Institute of Biomedical Imaging and Bioengineering; Canadian Institutes of Health Research; National Institutes of Health; H. Lundbeck A/S; Servier; National Natural Science Foundation of China; Eisai; Genentech; IXICO; Fudan University; Northern California Institute for Research and Education; Pfizer; Biogen; BioClinica; F. Hoffmann-La Roche; University of Southern California; Eli Lilly and Company; U.S. Department of Defense; Meso Scale Diagnostics; Alzheimer's Disease Neuroimaging Initiative; Novartis Pharmaceuticals Corporation; Bristol-Myers Squibb; Alzheimer's Association; Foundation for the National Institutes of Health","keywords":"Geriatric psychiatry; Biomarker; Neurology; Medicine; Internal medicine; Oncology; Psychiatry; Biology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":["insufficient_payload"],"category_scores_codex":[0.004775129,0.0004110477,0.0006278096,0.0006606921,0.0003875347,0.0002401158,0.00067325,0.0001675461,0.005434314],"category_scores_gemma":[0.0002060831,0.0002951271,0.0002903747,0.0008119264,0.0003546569,0.0003494584,0.0002935644,0.0008054854,0.001391691],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000676068,"about_ca_system_score_gemma":0.0004549676,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005569335,"about_ca_topic_score_gemma":0.00005465162,"domain_scores_codex":[0.9932366,0.001144291,0.0005046375,0.001322559,0.002220763,0.00157115],"domain_scores_gemma":[0.996145,0.0008269952,0.00007824656,0.001015217,0.001216216,0.0007182878],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.007212476,0.007879839,0.8915995,0.00001310584,0.005658474,0.0002917668,0.0005143326,1.898686e-7,0.003265677,0.0002092343,0.003116916,0.08023848],"study_design_scores_gemma":[0.01181762,0.03321414,0.9205374,0.00005647481,0.0003203209,0.00009913091,0.002995688,0.0001034367,0.007343024,0.000891739,0.02218936,0.0004317354],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9760222,0.008787299,0.00002444086,0.001532344,0.0001853959,0.01076555,0.0000252728,0.0001120884,0.002545437],"genre_scores_gemma":[0.9923983,0.001472964,0.000191735,0.0005363076,0.0002558911,0.004398709,0.0001230205,0.00008038233,0.0005427525],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.07980675,"threshold_uncertainty_score":0.9999501,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.3172691472317281,"score_gpt":0.4915587892679247,"score_spread":0.1742896420361967,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}