{"id":"W2953778562","doi":"10.1038/s41598-019-45982-7","title":"Retinoic acid and arsenic trioxide induce lasting differentiation and demethylation of target genes in APL cells","year":2019,"lang":"en","type":"article","venue":"Scientific Reports","topic":"Retinoids in leukemia and cellular processes","field":"Biochemistry, Genetics and Molecular Biology","cited_by":41,"is_retracted":false,"has_abstract":true,"ca_institutions":"Dalhousie University","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Killam Trusts; Dalhousie University; Government of Canada; Canadian Imperial Bank of Commerce; Beatrice Hunter Cancer Research Institute; Cancer Research Institute","keywords":"Arsenic trioxide; Acute promyelocytic leukemia; Retinoic acid; Tretinoin; Demethylation; Cancer research; Differentiation therapy; Epigenetic therapy; Acetylation; Chromatin immunoprecipitation; Combination therapy; Histone; Cellular differentiation; Epigenetics; Biology; Chemistry; DNA methylation; Medicine; Pharmacology; Gene expression; Biochemistry; Apoptosis; Gene; Promoter","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001461742,0.0002039006,0.0002976118,0.0001929893,0.0001074053,0.0001957456,0.0001561778,0.0002115698,0.001199065],"category_scores_gemma":[0.0001293242,0.0001564811,0.0002676964,0.0001966919,0.0001759921,0.0001396168,0.0002093017,0.0003967276,0.0003853504],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001688339,"about_ca_system_score_gemma":0.0001894513,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005679858,"about_ca_topic_score_gemma":0.001057899,"domain_scores_codex":[0.9998174,0.00003345431,0.00002073615,0.00004313744,0.00005265311,0.00003254114],"domain_scores_gemma":[0.9998996,0.0000170728,0.00002578595,0.00002335247,0.0000129652,0.00002119739],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001661851,0.00001626666,0.0001794617,0.00002163148,0.00000730411,0.00003642105,0.00001257192,0.00002705682,0.9983552,0.00002552273,0.00002145731,0.00113098],"study_design_scores_gemma":[0.00002998468,0.0007008957,0.009965865,0.000004254541,0.00002778167,0.0002692188,0.00004076381,0.0002796566,0.9862309,0.00004978845,0.002396414,0.000004459287],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9907618,0.004043809,0.002204629,0.00009029715,0.00003567422,0.00003723756,0.0005025395,0.00008322213,0.002240704],"genre_scores_gemma":[0.9919236,0.001319216,0.002413018,0.00007021847,0.00001389983,0.00005712152,0.0006207811,0.0000193822,0.003562652],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001199065,"threshold_uncertainty_score":0.004011273,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006256853365721529,"score_gpt":0.2141825340044238,"score_spread":0.2079256806387023,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}