{"id":"W2953778562","doi":"10.1038/s41598-019-45982-7","title":"Retinoic acid and arsenic trioxide induce lasting differentiation and demethylation of target genes in APL cells","year":2019,"lang":"en","type":"article","venue":"Scientific Reports","topic":"Retinoids in leukemia and cellular processes","field":"Biochemistry, Genetics and Molecular Biology","cited_by":41,"is_retracted":false,"has_abstract":true,"ca_institutions":"Dalhousie University","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Killam Trusts; Dalhousie University; Government of Canada; Canadian Imperial Bank of Commerce; Beatrice Hunter Cancer Research Institute; Cancer Research Institute","keywords":"Arsenic trioxide; Acute promyelocytic leukemia; Retinoic acid; Tretinoin; Demethylation; Cancer research; Differentiation therapy; Epigenetic therapy; Acetylation; Chromatin immunoprecipitation; Combination therapy; Histone; Cellular differentiation; Epigenetics; Biology; Chemistry; DNA methylation; Medicine; Pharmacology; Gene expression; Biochemistry; Apoptosis; Gene; Promoter","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006999396,0.00009458437,0.0001324363,0.00008402979,0.00004952566,0.00004619749,0.00004804628,0.0001083002,0.00001037351],"category_scores_gemma":[0.0001373761,0.0000884722,0.00002676302,0.0001452563,0.00009385093,0.00001135638,0.00007622084,0.00005885753,8.83563e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000088838,"about_ca_system_score_gemma":0.00007210501,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000006742695,"about_ca_topic_score_gemma":0.000007293146,"domain_scores_codex":[0.9988475,0.00004764154,0.0003295053,0.0004693623,0.0001546243,0.000151374],"domain_scores_gemma":[0.9993563,0.00001391444,0.000256389,0.0002616491,0.00007253943,0.0000391707],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000008461475,0.00001259311,0.09041411,0.00007381503,0.000005251386,0.000003453494,0.0000781774,0.00004162415,0.9082527,0.000006886701,0.00003201848,0.001070984],"study_design_scores_gemma":[0.0001639676,0.00003857495,0.00870612,0.00002865633,0.000007544085,0.00002421814,0.00007653566,0.0002314566,0.9890075,0.0006521993,0.0009652045,0.00009807276],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9963914,0.002061868,0.0003383013,0.000008226432,0.0008361779,0.0001685927,8.393873e-7,0.000004871934,0.0001896874],"genre_scores_gemma":[0.9982656,0.00008415675,0.0009792447,0.000004975331,0.0000323225,0.000004947081,0.00005741805,0.000008763839,0.0005625355],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.08170799,"threshold_uncertainty_score":0.3607792,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006256853365721529,"score_gpt":0.2141825340044238,"score_spread":0.2079256806387023,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}