{"id":"W2953803755","doi":"10.1016/j.chembiol.2019.06.002","title":"Discovery of a Novel DNA Gyrase-Targeting Antibiotic through the Chemical Perturbation of Streptomyces venezuelae Sporulation","year":2019,"lang":"en","type":"article","venue":"Cell chemical biology","topic":"Cancer therapeutics and mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":24,"is_retracted":false,"has_abstract":true,"ca_institutions":"Structural Genomics Consortium; McGill University Health Centre; University of Toronto","funders":"Biotechnology and Biological Sciences Research Council; Canadian Institutes of Health Research; Wellcome Trust","keywords":"DNA gyrase; Streptomyces; Biology; Antibiotics; DNA; Pathogenic bacteria; Microbiology; Novobiocin; Computational biology; Drug discovery; Human pathogen; Genetics; Bacteria; Escherichia coli; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001174019,0.0002558451,0.0002116794,0.0002638278,0.0001577189,0.0003028458,0.0001644745,0.0001878501,0.0007059611],"category_scores_gemma":[0.00009833158,0.0001057256,0.0001261705,0.0001264568,0.0002204812,0.0001056554,0.0001309755,0.0003955773,0.0001304904],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002699474,"about_ca_system_score_gemma":0.0003523516,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001311899,"about_ca_topic_score_gemma":0.003876496,"domain_scores_codex":[0.9999315,0.00001243412,0.000004146477,0.00001310691,0.00001933282,0.00001956183],"domain_scores_gemma":[0.9999497,0.000009352872,0.0000153166,0.000003909886,0.000007295794,0.00001455267],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006956577,0.0000428911,0.000291342,0.00005176305,0.000004544398,0.00007523424,0.00001260669,0.000261754,0.9940142,0.0003180105,0.00003479043,0.004823269],"study_design_scores_gemma":[0.00004016185,0.000876685,0.002509787,0.00001228719,0.00001815783,0.0002857344,0.00002166355,0.00108905,0.9898817,0.00008162547,0.005176441,0.000006753918],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9810921,0.004669528,0.008365662,0.0002221884,0.00004589575,0.0001231831,0.0002110037,0.0001268458,0.005143681],"genre_scores_gemma":[0.9890115,0.002113112,0.006092221,0.0000515043,0.000009510853,0.00002315153,0.0001799687,0.00001156999,0.00250735],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001311899,"threshold_uncertainty_score":0.002608538,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01071538243576564,"score_gpt":0.2446955013550505,"score_spread":0.2339801189192849,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}