{"id":"W2953877276","doi":"10.1016/j.jalz.2019.04.007","title":"Individualized atrophy scores predict dementia onset in familial frontotemporal lobar degeneration","year":2019,"lang":"en","type":"article","venue":"Alzheimer s & Dementia","topic":"Dementia and Cognitive Impairment Research","field":"Medicine","cited_by":40,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; University of Toronto","funders":"National Institute of Neurological Disorders and Stroke; National Institute on Aging; Janssen Pharmaceuticals; Alzheimer Society of B.C.; Canadian Institutes of Health Research; Avid Radiopharmaceuticals; University of California, San Diego; Association for Frontotemporal Degeneration; National Institutes of Health; Eisai; Little Family Foundation; New York State Department of Health; University of Pennsylvania; University of Southern California; Alzheimer's Drug Discovery Foundation; Parkinsonfonden; University of California, San Francisco; Alzheimer Society; U.S. Department of Defense; BrightFocus Foundation; Eli Lilly and Company; Tau Consortium; Bristol-Myers Squibb; Allergan; AstraZeneca; Genentech; Larry L. Hillblom Foundation; TauRx Pharmaceuticals; Sol Goldman Charitable Trust; Ionis Pharmaceuticals; Alzheimer's Association; Pfizer; Biogen; Mayo Clinic; Amgen","keywords":"Frontotemporal lobar degeneration; Frontotemporal dementia; Medicine; Atrophy; Dementia; Pediatrics; Neuroscience; Pathology; Psychology; Disease","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009412389,0.0004732097,0.0002382958,0.0008205254,0.0002937168,0.0003773065,0.0002174368,0.000452831,0.00114047],"category_scores_gemma":[0.003826968,0.0001892545,0.0002249425,0.0003377135,0.0002227001,0.0002743675,0.0003225533,0.0003928375,0.0002076155],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002875183,"about_ca_system_score_gemma":0.0001852791,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003421101,"about_ca_topic_score_gemma":0.006277786,"domain_scores_codex":[0.9998078,0.00007945538,0.00001864639,0.00004169782,0.00003391529,0.00001851445],"domain_scores_gemma":[0.9983564,0.0004264569,0.000872485,0.00008621402,0.0001247415,0.0001337085],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0001796544,0.00002954325,0.9951091,0.000006323147,0.00003716309,0.00007415489,0.00008260544,0.0002252176,0.0002241711,0.00001989057,0.0001017727,0.003910435],"study_design_scores_gemma":[0.000006351817,0.0001009131,0.9981609,0.000008140518,0.00002770151,0.0003343064,0.00005353868,0.0009271591,0.0001934524,0.0001175154,0.00006524683,0.000004805585],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9994048,0.0001291938,0.0001514536,0.0000218292,0.000001728449,0.000003120994,0.00006195191,0.000009643015,0.0002162355],"genre_scores_gemma":[0.9994813,0.00003603537,0.0002758417,0.000005772569,0.000002431811,0.00000290087,0.0001055656,0.000001278654,0.00008901962],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003421101,"threshold_uncertainty_score":0.00680238,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02223323623433953,"score_gpt":0.2947584902767263,"score_spread":0.2725252540423868,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}