{"id":"W2953901678","doi":"10.1126/science.aax9108","title":"Mutation hotspots may not be drug targets","year":2019,"lang":"en","type":"letter","venue":"Science","topic":"Cancer Genomics and Diagnostics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institutes of Health; European Commission; Canadian Institute for Advanced Research","keywords":"Mutation; Drug; Genetics; Biology; Computational biology; Gene; Pharmacology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002686194,0.0004709837,0.001189655,0.0004522035,0.001621077,0.002198987,0.0009396708,0.02175101,0.004292938],"category_scores_gemma":[0.01306181,0.000477324,0.0005899984,0.0003699055,0.002961861,0.00267678,0.001255922,0.01946316,0.003695155],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002036173,"about_ca_system_score_gemma":0.0006895231,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005323265,"about_ca_topic_score_gemma":0.001279285,"domain_scores_codex":[0.9982752,0.0005281559,0.0001895414,0.0002862749,0.0004611458,0.0002597158],"domain_scores_gemma":[0.9927066,0.004524309,0.0006426339,0.0005222069,0.0007511611,0.0008531905],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0005574737,0.0001411517,0.005593654,0.0003587744,0.0001381648,0.02672221,0.0004039613,0.0004753257,0.006555914,0.04339836,0.8208245,0.09483048],"study_design_scores_gemma":[0.0005417288,0.0003031959,0.003989373,0.0002037503,0.00009304674,0.02763562,0.000435529,0.00121241,0.004769045,0.08075685,0.8799624,0.0000970742],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.005909079,0.008157935,0.001209343,0.9547063,0.0210782,0.00001770916,0.00003889328,0.00009553273,0.008787054],"genre_scores_gemma":[0.09221873,0.00702281,0.001274441,0.794807,0.08717138,0.00007376407,0.00005347497,0.00008663304,0.01729184],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.02175101,"threshold_uncertainty_score":0.01477349,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01016828660164402,"score_gpt":0.2539049721858853,"score_spread":0.2437366855842412,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}