{"id":"W2953939482","doi":"10.1158/1538-7445.am2019-ct190","title":"Abstract CT190: A Phase II basket study of hypomethylating agent oral cc-486 and durvalumab in advanced solid tumors (METADUR)","year":2019,"lang":"en","type":"article","venue":"Cancer Research","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"","keywords":"Durvalumab; Medicine; Regimen; Hypomethylating agent; Internal medicine; Cancer; Immune system; Breast cancer; Immune checkpoint; Oncology; Adverse effect; Immunology; Gastroenterology; Immunotherapy; Nivolumab; DNA methylation; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001263337,0.001515403,0.001952963,0.0005987852,0.0003807616,0.001032742,0.001209988,0.001104214,0.004775444],"category_scores_gemma":[0.0007226704,0.0006485787,0.0009646869,0.000580866,0.0006325573,0.0008286822,0.0003930752,0.002735532,0.001038838],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001259634,"about_ca_system_score_gemma":0.001800965,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001861969,"about_ca_topic_score_gemma":0.005175746,"domain_scores_codex":[0.9996729,0.0001311347,0.00001844084,0.00005934602,0.00003717922,0.00008093219],"domain_scores_gemma":[0.9995623,0.00005149202,0.00009026063,0.00004061237,0.00002900847,0.0002263893],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.6144614,0.06915474,0.007395377,0.001227479,0.00183292,0.000484549,0.0003909571,0.003045336,0.1440874,0.0008548679,0.007712306,0.1493527],"study_design_scores_gemma":[0.5255587,0.449598,0.009770794,0.00004197225,0.0004618236,0.0005928337,0.00007682605,0.00156307,0.007857229,0.0002623888,0.004173385,0.00004297263],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9901698,0.001976833,0.0006232223,0.000433395,0.00009882074,0.002902929,0.001607131,0.000160668,0.002027228],"genre_scores_gemma":[0.9866704,0.00189505,0.002177556,0.0005766923,0.0001131253,0.002403311,0.002837688,0.00004592417,0.003280248],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004775444,"threshold_uncertainty_score":0.01597542,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06244591674657703,"score_gpt":0.4374362417948338,"score_spread":0.3749903250482568,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}