{"id":"W2953971302","doi":"10.1158/1538-7445.am2019-ct058","title":"Abstract CT058: Ripretinib (DCC-2618) pharmacokinetics (PK) in a Phase I study in patients with gastrointestinal stromal tumors (GIST) and other advanced malignancies: A retrospective evaluation of the PK effects of proton pump inhibitors (PPIs)","year":2019,"lang":"en","type":"article","venue":"Cancer Research","topic":"Gastrointestinal Tumor Research and Treatment","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"","keywords":"Medicine; GiST; Tolerability; Pharmacokinetics; Concomitant; Retrospective cohort study; Internal medicine; Gastroenterology; Pharmacology; Drug; Oncology; Adverse effect; Stromal cell","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001733914,0.0005341114,0.001154886,0.0003765559,0.0002852244,0.0008550875,0.0004917186,0.0004280944,0.002467585],"category_scores_gemma":[0.00216796,0.000331865,0.001110878,0.0006184988,0.0006507622,0.0007234056,0.0003088915,0.00133062,0.0005748332],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009606023,"about_ca_system_score_gemma":0.00105698,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000606987,"about_ca_topic_score_gemma":0.0009444525,"domain_scores_codex":[0.9989987,0.0004129109,0.00008885616,0.0002453816,0.0001824845,0.00007171962],"domain_scores_gemma":[0.9983878,0.0003094995,0.0006502517,0.0002244036,0.0001130048,0.0003150851],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"observational","study_design_scores_codex":[0.5246849,0.01321455,0.2285883,0.0009351934,0.004281803,0.0009746859,0.0003926641,0.004918573,0.08702315,0.0002979735,0.003663393,0.1310249],"study_design_scores_gemma":[0.1177804,0.3773753,0.4541234,0.00009879417,0.003741303,0.005133629,0.0001984363,0.006273153,0.02249898,0.0003075172,0.01234014,0.0001289945],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9959043,0.001255575,0.0003743917,0.00006294886,0.00001240112,0.0003450345,0.00115002,0.00002902594,0.0008664186],"genre_scores_gemma":[0.9954948,0.0003665931,0.0007529546,0.0001494574,0.00003086941,0.0001964524,0.0025019,0.00001218568,0.0004947313],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002467585,"threshold_uncertainty_score":0.009169936,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03439763882485165,"score_gpt":0.3950837320658938,"score_spread":0.3606860932410421,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}