{"id":"W2953975624","doi":"10.1007/s00018-019-03203-4","title":"Mechanisms of PINK1, ubiquitin and Parkin interactions in mitochondrial quality control and beyond","year":2019,"lang":"en","type":"review","venue":"Cellular and Molecular Life Sciences","topic":"Mitochondrial Function and Pathology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":113,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University","funders":"Natural Sciences and Engineering Research Council of Canada; Canada First Research Excellence Fund; Canada Research Chairs; Canadian Institutes of Health Research; Parkinson Society Canada; Michael J. Fox Foundation for Parkinson's Research","keywords":"Parkin; PINK1; Ubiquitin; Ubiquitin-Protein Ligases; Cell biology; Mitophagy; Mitochondrion; Control (management); Ubiquitin ligase; Biology; Genetics; Computer science; Autophagy; Medicine; Internal medicine; Parkinson's disease","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007993649,0.001120867,0.001429828,0.00179248,0.0003142075,0.001455153,0.001148613,0.001474906,0.002740445],"category_scores_gemma":[0.0006216923,0.0002698087,0.000331266,0.002248117,0.0008195794,0.002121048,0.001159935,0.001924911,0.001983524],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001048718,"about_ca_system_score_gemma":0.001074509,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007875564,"about_ca_topic_score_gemma":0.001438289,"domain_scores_codex":[0.9998466,0.00002333227,0.00002076938,0.00003056574,0.00005811504,0.00002062332],"domain_scores_gemma":[0.9997603,0.0001034187,0.00003463108,0.000009753641,0.00005929928,0.000032435],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001881177,0.00007573912,0.0001486579,0.01557136,0.0000829929,0.0003768818,0.0000839138,0.0008113623,0.005612783,0.01610086,0.04026381,0.9206835],"study_design_scores_gemma":[0.00001762551,0.00006137376,0.0005352061,0.002130279,0.00006690442,0.0007953862,0.00005954861,0.0001337028,0.0006887923,0.00634253,0.9891477,0.00002103744],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00007126646,0.9987401,0.0001359864,0.0002618967,0.0001852717,0.000001839527,0.00001061388,0.00000509968,0.0005879277],"genre_scores_gemma":[0.0004077757,0.9986441,0.0001252043,0.000142147,0.0001812895,0.000003242411,0.00001670927,7.293223e-7,0.0004788793],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002740445,"threshold_uncertainty_score":0.009167671,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03889378874444267,"score_gpt":0.328727918973396,"score_spread":0.2898341302289534,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}