{"id":"W2953984911","doi":"10.82308/49800","title":"Endothelial cell response to simvastatin and fluid wall shear stress: an investigation into statin-shear stress interactions","year":2010,"lang":"en","type":"article","venue":"eScholarship@McGill (McGill)","topic":"Kruppel-like factors research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Canadian Institutes of Health Research; Fonds Québécois de la Recherche sur la Nature et les Technologies; Natural Sciences and Engineering Research Council of Canada; McGill University","keywords":"Simvastatin; Statin; KLF2; Endothelium; Enos; Endothelial stem cell; Thrombomodulin; Nitric oxide; Internal medicine; Medicine; Pharmacology; Endocrinology; Chemistry; Nitric oxide synthase; Platelet; Biochemistry; Downregulation and upregulation; In vitro","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002381538,0.0001331899,0.0003308904,0.000156394,0.0001705287,0.0003238317,0.0001206162,0.0002912845,0.001532812],"category_scores_gemma":[0.0001381236,0.0001086519,0.0003164873,0.0002279944,0.0001557076,0.0002433846,0.0001224602,0.0003729177,0.0002110313],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002032114,"about_ca_system_score_gemma":0.0002143359,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005495306,"about_ca_topic_score_gemma":0.0006980058,"domain_scores_codex":[0.999843,0.00002853794,0.00001362809,0.00002872,0.00004138354,0.00004480841],"domain_scores_gemma":[0.9999268,0.00001574295,0.00001407246,0.000006696255,0.00001823791,0.00001839219],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008333326,0.00009830151,0.001371931,0.00007391061,0.00001539315,0.00005143461,0.00005601831,0.00006278494,0.9947792,0.00007086377,0.0000367445,0.002550133],"study_design_scores_gemma":[0.00008614733,0.003277795,0.05955885,0.00001517666,0.0001044567,0.0002407126,0.0003784923,0.002430747,0.930123,0.0001418365,0.003627812,0.00001500808],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.994606,0.002558175,0.001455215,0.0000954898,0.00003756509,0.00002615622,0.0001753102,0.00001242357,0.00103361],"genre_scores_gemma":[0.9937152,0.001906593,0.001246718,0.0001229436,0.00002369857,0.00006958957,0.0002245023,0.000003839194,0.002686804],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001532812,"threshold_uncertainty_score":0.005127788,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01397477928184914,"score_gpt":0.2750018041726105,"score_spread":0.2610270248907613,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}