{"id":"W2954063027","doi":"10.1002/path.5319","title":"Integrative genomic analysis of matched primary and metastatic pediatric osteosarcoma","year":2019,"lang":"en","type":"article","venue":"The Journal of Pathology","topic":"Sarcoma Diagnosis and Treatment","field":"Medicine","cited_by":54,"is_retracted":false,"has_abstract":true,"ca_institutions":"SickKids Foundation; University of Toronto; Hospital for Sick Children; University of British Columbia; Canada's Michael Smith Genome Sciences Centre; McGill University Health Centre; Simon Fraser University; BC Cancer Agency","funders":"National Cancer Institute; Genome Canada; Canadian Institutes of Health Research; Genome British Columbia; Michael Smith Health Research BC; St. Baldrick's Foundation","keywords":"Osteosarcoma; Primary tumor; Exome sequencing; Somatic hypermutation; Genome instability; Germline; Biology; Copy-number variation; Exome; Cancer; Metastasis; Gene; Cancer research; Genome; Medicine; Mutation; Genetics; DNA; DNA damage; Antibody","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005489729,0.00009205299,0.0006903428,0.0003509239,0.00001530146,0.000002724035,0.0000771194,0.00002936197,0.00009724243],"category_scores_gemma":[0.00004088823,0.00004573425,0.0001753057,0.0002894894,0.0000620017,0.00002905807,0.00003584789,0.0001422849,0.000008297421],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004025237,"about_ca_system_score_gemma":0.0000613692,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000009845166,"about_ca_topic_score_gemma":0.000005467519,"domain_scores_codex":[0.9991087,0.0002086253,0.0003824641,0.00007051262,0.0001296736,0.00009999669],"domain_scores_gemma":[0.9987918,0.0004548046,0.0004228078,0.0001708178,0.0001114907,0.0000483074],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0004646273,0.0003935732,0.9706871,0.00005487659,0.002451181,0.0005176463,0.002905278,0.00003059123,0.0192258,0.0001296121,0.00007923358,0.003060514],"study_design_scores_gemma":[0.001493448,0.0009470197,0.9830536,0.0000136265,0.01109878,0.001521581,0.0009215781,0.00004632493,0.0006758653,0.000170641,0.00001706916,0.00004043158],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9925477,0.00641973,0.00007858301,0.0005553233,0.00005904975,0.0001448883,0.000007632247,0.000001975932,0.0001851029],"genre_scores_gemma":[0.9972597,0.001357461,0.001075229,0.0002149336,0.00002984509,0.000001425698,0.00000346449,0.000006843306,0.00005107667],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01854993,"threshold_uncertainty_score":0.1864989,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0147472996854169,"score_gpt":0.2757684113142397,"score_spread":0.2610211116288229,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}