{"id":"W2954075939","doi":"10.1016/j.str.2019.06.005","title":"Structural Basis for Recruitment of DAPK1 to the KLHL20 E3 Ligase","year":2019,"lang":"en","type":"article","venue":"Structure","topic":"Ubiquitin and proteasome pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":37,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Medical Research Council; Merck Sharp and Dohme; Janssen Biotech; Innovative Medicines Initiative; Genome Canada; Fundação de Amparo à Pesquisa do Estado de São Paulo; Cancer Research UK; China Scholarship Council; Canada Foundation for Innovation; Novartis Pharma; Wellcome Trust; Ontario Ministry of Economic Development and Innovation; AbbVie; Pfizer","keywords":"Ubiquitin ligase; DNA ligase; Biology; Genetics; Computational biology; Chemistry; Biochemistry; Ubiquitin; Enzyme; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008038373,0.0001269535,0.0001284114,0.00001898478,0.00005437145,0.00001286319,0.0002502491,0.0001069981,0.0001349648],"category_scores_gemma":[0.00006037152,0.00008250023,0.00009529894,0.00006155565,0.00002446579,0.000001811934,0.0000918472,0.00006292303,0.000006757191],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000008763686,"about_ca_system_score_gemma":0.00004456538,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000008807508,"about_ca_topic_score_gemma":0.00002389014,"domain_scores_codex":[0.999294,0.00002940297,0.0001392831,0.0002457866,0.0001018794,0.0001896118],"domain_scores_gemma":[0.9993628,0.00001445875,0.00006520614,0.0004271,0.00007181837,0.00005863208],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000141801,0.000003317947,0.0006412767,0.00004528227,0.00004200479,2.018511e-7,0.0002044828,0.0001053461,0.9883189,0.0007622301,0.001925217,0.007809964],"study_design_scores_gemma":[0.0003018867,0.0003515585,0.002147473,0.00001173902,0.00001303849,0.000005876216,0.00009602238,0.00002601482,0.9051502,0.0004729719,0.09130566,0.0001175866],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9966463,0.0002431657,0.00007786771,0.0004846719,0.0003310259,0.00121692,0.0004813601,0.000006079073,0.0005126199],"genre_scores_gemma":[0.9967047,0.000006962703,0.001526022,0.0006448558,0.0002916367,0.00005771823,0.0001126652,0.00001700732,0.0006384248],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.08938044,"threshold_uncertainty_score":0.3364262,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02503612897753916,"score_gpt":0.2806320741782315,"score_spread":0.2555959452006923,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}