{"id":"W2954075939","doi":"10.1016/j.str.2019.06.005","title":"Structural Basis for Recruitment of DAPK1 to the KLHL20 E3 Ligase","year":2019,"lang":"en","type":"article","venue":"Structure","topic":"Ubiquitin and proteasome pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":37,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Medical Research Council; Merck Sharp and Dohme; Janssen Biotech; Innovative Medicines Initiative; Genome Canada; Fundação de Amparo à Pesquisa do Estado de São Paulo; Cancer Research UK; China Scholarship Council; Canada Foundation for Innovation; Novartis Pharma; Wellcome Trust; Ontario Ministry of Economic Development and Innovation; AbbVie; Pfizer","keywords":"Ubiquitin ligase; DNA ligase; Biology; Genetics; Computational biology; Chemistry; Biochemistry; Ubiquitin; Enzyme; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008331201,0.000189518,0.0001934384,0.00008308327,0.0003185248,0.0002983126,0.0003592526,0.0003031147,0.001432361],"category_scores_gemma":[0.0001532741,0.0001392547,0.0001199343,0.00007002793,0.0001961142,0.0001728763,0.0002407452,0.0003456054,0.0004464602],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007683629,"about_ca_system_score_gemma":0.0004195133,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001153127,"about_ca_topic_score_gemma":0.001365804,"domain_scores_codex":[0.9999382,0.000008396702,0.00000410239,0.00001344232,0.00001829946,0.00001748047],"domain_scores_gemma":[0.9999397,0.000005383772,0.00001459274,0.000003511174,0.00000858472,0.00002829357],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005040776,0.0001378637,0.002382887,0.00009386345,0.00001689952,0.00105107,0.00007176713,0.00456466,0.9856837,0.001885315,0.0005649998,0.003042857],"study_design_scores_gemma":[0.0003506022,0.0006576143,0.04051484,0.00003858959,0.00004449847,0.002066673,0.000334041,0.07438159,0.8691872,0.002746913,0.009626484,0.00005095536],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9947016,0.0003853791,0.002415528,0.000190026,0.00001979384,0.00001742223,0.0001238755,0.000132173,0.002014175],"genre_scores_gemma":[0.9983307,0.00009724245,0.0008049521,0.00006418648,0.000002780852,0.00000513399,0.0001500273,0.000007986258,0.000537042],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001432361,"threshold_uncertainty_score":0.005574882,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02503612897753916,"score_gpt":0.2806320741782315,"score_spread":0.2555959452006923,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}