{"id":"W2954084404","doi":"10.1038/s41467-019-09773-y","title":"A systems biology approach uncovers cell-specific gene regulatory effects of genetic associations in multiple sclerosis","year":2019,"lang":"en","type":"review","venue":"Nature Communications","topic":"Genomics and Chromatin Dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":82,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Centre Hospitalier de l’Université de Montréal","funders":"National Institute of Environmental Health Sciences; National Institute of Neurological Disorders and Stroke; Medical Research Council; H. Lundbeck A/S; National Multiple Sclerosis Society; Norges Forskningsråd; Vlaamse regering; Forskningsrådet om Hälsa, Arbetsliv och Välfärd; Vetenskapsrådet; Knut och Alice Wallenbergs Stiftelse; KU Leuven; Fonds Wetenschappelijk Onderzoek; AFA Försäkring; Wellcome Trust; National Institute of Allergy and Infectious Diseases; Agence Nationale de la Recherche; European Commission; Bundesministerium für Bildung und Forschung; National Institute for Health and Care Research; Multiple Sclerosis Society; King's College London; Valhalla Foundation; Fondation pour l'Aide à la Recherche sur la Sclérose en Plaques; National Institutes of Health; Harvard NeuroDiscovery Center; Lundbeckfonden; Institut National de la Santé et de la Recherche Médicale","keywords":"Multiple sclerosis; Gene; Computational biology; Biology; Genetics; Systems biology; Gene regulatory network; Evolutionary biology; Gene expression; Immunology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000913377,0.001005202,0.001354653,0.002048385,0.000222283,0.001047123,0.001067111,0.001218178,0.001729963],"category_scores_gemma":[0.0008446698,0.0003543502,0.0006104404,0.001585988,0.00103035,0.001249713,0.0007773938,0.001988332,0.00143682],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009846395,"about_ca_system_score_gemma":0.000938745,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001002545,"about_ca_topic_score_gemma":0.001470783,"domain_scores_codex":[0.9997975,0.00005561134,0.00001983103,0.00005078617,0.00005768724,0.00001858933],"domain_scores_gemma":[0.9995261,0.0003032257,0.00003923034,0.00002450509,0.00007976374,0.00002716733],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"observational","study_design_scores_codex":[0.00009873726,0.00005467718,0.0004592771,0.01148216,0.0002604282,0.0002787852,0.00006136638,0.001567618,0.004522498,0.02649109,0.02234971,0.9323737],"study_design_scores_gemma":[0.00003721015,0.0001675563,0.002139132,0.002906511,0.0002445164,0.001209869,0.0000737075,0.0008687613,0.002222347,0.02323445,0.9668475,0.00004828659],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.000183297,0.996799,0.001100212,0.0006247121,0.0002000405,0.00000675875,0.00002637863,0.00001706641,0.001042527],"genre_scores_gemma":[0.001498757,0.9966807,0.0008023662,0.0002956358,0.0001703652,0.00001198566,0.00003878208,0.000003408606,0.0004980208],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002048385,"threshold_uncertainty_score":0.007144094,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03618800693504299,"score_gpt":0.2709371313266342,"score_spread":0.2347491243915912,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}