{"id":"W2954084404","doi":"10.1038/s41467-019-09773-y","title":"A systems biology approach uncovers cell-specific gene regulatory effects of genetic associations in multiple sclerosis","year":2019,"lang":"en","type":"review","venue":"Nature Communications","topic":"Genomics and Chromatin Dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":82,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Centre Hospitalier de l’Université de Montréal","funders":"National Institute of Environmental Health Sciences; National Institute of Neurological Disorders and Stroke; Medical Research Council; H. Lundbeck A/S; National Multiple Sclerosis Society; Norges Forskningsråd; Vlaamse regering; Forskningsrådet om Hälsa, Arbetsliv och Välfärd; Vetenskapsrådet; Knut och Alice Wallenbergs Stiftelse; KU Leuven; Fonds Wetenschappelijk Onderzoek; AFA Försäkring; Wellcome Trust; National Institute of Allergy and Infectious Diseases; Agence Nationale de la Recherche; European Commission; Bundesministerium für Bildung und Forschung; National Institute for Health and Care Research; Multiple Sclerosis Society; King's College London; Valhalla Foundation; Fondation pour l'Aide à la Recherche sur la Sclérose en Plaques; National Institutes of Health; Harvard NeuroDiscovery Center; Lundbeckfonden; Institut National de la Santé et de la Recherche Médicale","keywords":"Multiple sclerosis; Gene; Computational biology; Biology; Genetics; Systems biology; Gene regulatory network; Evolutionary biology; Gene expression; Immunology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity"],"consensus_categories":[],"category_scores_codex":[0.0002416474,0.0003275624,0.0009431436,0.0001927763,0.00009933947,0.00002305481,0.001473562,0.001550423,5.825656e-7],"category_scores_gemma":[0.0001074496,0.0003242168,0.0003690978,0.0003365008,0.0001201567,0.000002520045,0.0005655048,0.0007533098,0.000007144015],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001902071,"about_ca_system_score_gemma":0.0002752072,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003245863,"about_ca_topic_score_gemma":0.00004063956,"domain_scores_codex":[0.9979897,0.0005272821,0.0006883666,0.0004392888,0.0001098143,0.0002455144],"domain_scores_gemma":[0.9959817,0.000281341,0.0007082379,0.002849517,0.0001279315,0.00005128643],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00009260912,0.01241226,0.02290401,0.1338902,0.007967842,0.000008424032,0.001557709,0.009338887,0.1665064,0.02427668,0.04813717,0.5729077],"study_design_scores_gemma":[0.0009869897,0.0001293439,0.001954083,0.001941705,0.0005617096,0.000008928577,0.00004531297,0.000703735,0.0002595266,0.0000221109,0.9925422,0.0008443394],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00175071,0.9954868,0.0002492407,0.000005123731,0.0003478701,0.001239958,0.0004682662,0.000009758422,0.0004422832],"genre_scores_gemma":[0.09418231,0.8952551,0.005733344,0.00001247518,0.00007262827,0.000239437,0.004369286,0.00006074714,0.00007460795],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.944405,"threshold_uncertainty_score":0.999921,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03618800693504299,"score_gpt":0.2709371313266342,"score_spread":0.2347491243915912,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}