{"id":"W2954141193","doi":"10.1111/adb.12799","title":"A randomized, double‐blind, placebo‐controlled study of the kappa opioid receptor antagonist, CERC‐501, in a human laboratory model of smoking behavior","year":2019,"lang":"en","type":"article","venue":"Addiction Biology","topic":"Smoking Behavior and Cessation","field":"Medicine","cited_by":24,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute on Drug Abuse; Canada Excellence Research Chairs, Government of Canada; Cerecor","keywords":"Kappa; Antagonist; Placebo; Pharmacology; κ-opioid receptor; Receptor antagonist; Opioid; Psychology; Medicine; Anesthesia; Internal medicine; Receptor; Mathematics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001794642,0.001185252,0.003206936,0.0006569843,0.0008831569,0.0006529192,0.0008444838,0.001910771,0.004588309],"category_scores_gemma":[0.001720351,0.0009867168,0.0007750652,0.0004235856,0.001793511,0.0008554808,0.0003784383,0.001882708,0.000782272],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004972597,"about_ca_system_score_gemma":0.00167977,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008289629,"about_ca_topic_score_gemma":0.001892483,"domain_scores_codex":[0.9989914,0.0004315455,0.00009783478,0.0002232601,0.0001147137,0.0001411291],"domain_scores_gemma":[0.9988402,0.0002987818,0.0002485841,0.0001702263,0.0001184905,0.0003237643],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9200168,0.03768241,0.0005399493,0.0003781158,0.0002783203,0.00003869425,0.00006634314,0.0002038034,0.02543484,0.0001642835,0.0004771859,0.01471926],"study_design_scores_gemma":[0.7085202,0.2855387,0.002123041,0.00001656639,0.0002057261,0.00003426503,0.00002255617,0.0004734252,0.002423035,0.00008529578,0.0005339122,0.00002327227],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9895021,0.0009705849,0.001209184,0.0002147809,0.0003184133,0.006386152,0.0004599378,0.0001004046,0.0008383978],"genre_scores_gemma":[0.9787718,0.001624201,0.004644895,0.0006462567,0.00044356,0.01017865,0.0007487046,0.00003253768,0.002909411],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004588309,"threshold_uncertainty_score":0.01534939,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03418915555059524,"score_gpt":0.3219349051832047,"score_spread":0.2877457496326095,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}