{"id":"W2954202342","doi":"10.1200/jco.2019.37.15_suppl.7518","title":"Managing cytokine release syndrome (CRS) and neurotoxicity with step-fractionated dosing of mosunetuzumab in relapsed/refractory (R/R) B-cell non-Hodgkin lymphoma (NHL).","year":2019,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":21,"is_retracted":false,"has_abstract":true,"ca_institutions":"Jewish General Hospital; Spinal Cord Injury BC; University of British Columbia","funders":"","keywords":"Medicine; Cytokine release syndrome; Adverse effect; Dosing; Gastroenterology; Chills; Internal medicine; Refractory (planetary science); Lymphoma; Cancer; Immunotherapy; Chimeric antigen receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003483201,0.0002829689,0.0003704938,0.0001629647,0.000143781,0.0001790401,0.0003057075,0.0001852263,0.0005577195],"category_scores_gemma":[0.0004030508,0.00007795596,0.0002191495,0.0001233315,0.0001366104,0.000194559,0.0001520739,0.0005291248,0.0001388879],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003316253,"about_ca_system_score_gemma":0.0002673426,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004183681,"about_ca_topic_score_gemma":0.0014561,"domain_scores_codex":[0.9999181,0.00002539527,0.000009117819,0.00001070929,0.0000193148,0.00001744933],"domain_scores_gemma":[0.9998519,0.0000318434,0.00006573655,0.00001268618,0.00001035697,0.00002737815],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.01815611,0.004568637,0.0612283,0.0009424742,0.0005272222,0.001648746,0.0004132556,0.004361137,0.1659347,0.0001826192,0.002176096,0.7398607],"study_design_scores_gemma":[0.01876697,0.2988062,0.5211295,0.0003200212,0.0009965955,0.0192176,0.0002572976,0.009851281,0.1123612,0.0005732941,0.01766515,0.00005485422],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9962684,0.002281997,0.0005420965,0.00006744894,0.000006904354,0.0001228375,0.00005755344,0.00003028694,0.0006223955],"genre_scores_gemma":[0.9982291,0.0007380181,0.0006261289,0.00006997797,0.00001439864,0.00004584674,0.00009443887,0.000003547916,0.000178673],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0005577195,"threshold_uncertainty_score":0.00240612,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0451351166116556,"score_gpt":0.3907390396098182,"score_spread":0.3456039229981626,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}