{"id":"W2954202342","doi":"10.1200/jco.2019.37.15_suppl.7518","title":"Managing cytokine release syndrome (CRS) and neurotoxicity with step-fractionated dosing of mosunetuzumab in relapsed/refractory (R/R) B-cell non-Hodgkin lymphoma (NHL).","year":2019,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":21,"is_retracted":false,"has_abstract":true,"ca_institutions":"Jewish General Hospital; Spinal Cord Injury BC; University of British Columbia","funders":"","keywords":"Medicine; Cytokine release syndrome; Adverse effect; Dosing; Gastroenterology; Chills; Internal medicine; Refractory (planetary science); Lymphoma; Cancer; Immunotherapy; Chimeric antigen receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00343253,0.000213867,0.001829782,0.0004942265,0.00003188336,0.00001250273,0.0002096833,0.0004287735,0.0006528783],"category_scores_gemma":[0.0008476427,0.0001624148,0.0002573968,0.0004168142,0.0002888008,0.0001906395,0.0001017353,0.001667727,0.00001669924],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003992383,"about_ca_system_score_gemma":0.00154547,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001520416,"about_ca_topic_score_gemma":0.0000455823,"domain_scores_codex":[0.995664,0.0006535788,0.002240214,0.0003524209,0.0007183193,0.0003714615],"domain_scores_gemma":[0.9942112,0.002858901,0.001727306,0.0003655101,0.0004234234,0.0004136779],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.1007909,0.009918978,0.3964956,0.000715451,0.0007514464,0.01411763,0.0002510784,0.0005708289,0.1404698,0.00002108896,0.0008859553,0.3350112],"study_design_scores_gemma":[0.07329665,0.06592251,0.8209594,0.0009596563,0.0003128399,0.006314737,0.0003676218,0.0082146,0.002781214,0.0001205406,0.0204174,0.0003327878],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9927292,0.0002595177,0.00007835965,0.00152052,0.0004202512,0.0005783346,0.000002723307,0.00001017779,0.004400936],"genre_scores_gemma":[0.9955553,0.0009720084,0.001345623,0.0006439245,0.0001850834,0.000003907632,0.000002203736,0.00004635315,0.001245619],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4244638,"threshold_uncertainty_score":0.7245536,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0451351166116556,"score_gpt":0.3907390396098182,"score_spread":0.3456039229981626,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}