{"id":"W2954232647","doi":"10.1074/mcp.ra119.001612","title":"Multi-omics Biomarker Pipeline Reveals Elevated Levels of Protein-glutamine Gamma-glutamyltransferase 4 in Seminal Plasma of Prostate Cancer Patients","year":2019,"lang":"en","type":"article","venue":"Molecular & Cellular Proteomics","topic":"Prostate Cancer Treatment and Research","field":"Medicine","cited_by":46,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lunenfeld-Tanenbaum Research Institute; University of Calgary; University of Toronto; University Health Network; Mount Sinai Hospital","funders":"Canadian Institutes of Health Research; Prostate Cancer Canada; Government of Canada","keywords":"Prostate cancer; Biomarker; Prostate; Biomarker discovery; Proteomics; Cancer; PCA3; Cancer biomarkers; Medicine; Oncology; Cancer research; Internal medicine; Biology; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001271967,0.0007975412,0.0007391129,0.0012168,0.0004333984,0.001398947,0.00029686,0.0005962509,0.002379518],"category_scores_gemma":[0.001766755,0.0002214506,0.00102114,0.001240032,0.0002179721,0.0004461454,0.0009607107,0.0006609928,0.0008134871],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000471909,"about_ca_system_score_gemma":0.0009834691,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002353883,"about_ca_topic_score_gemma":0.00341851,"domain_scores_codex":[0.9993955,0.0001352487,0.00004988318,0.0002164819,0.0001197163,0.00008307115],"domain_scores_gemma":[0.9996308,0.000111153,0.00008620881,0.00003689766,0.000087073,0.00004788342],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.004100172,0.0002993454,0.6741603,0.00144702,0.003071177,0.0007954612,0.0004760444,0.007038762,0.165316,0.001214639,0.01438044,0.1277006],"study_design_scores_gemma":[0.0001590241,0.001058588,0.8246037,0.0003340788,0.001812872,0.002852193,0.001027234,0.04669381,0.07761788,0.005581,0.03808233,0.0001772512],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9289784,0.01118008,0.01504071,0.002429366,0.0003505195,0.00010653,0.03597185,0.001687519,0.004255051],"genre_scores_gemma":[0.9700724,0.001396814,0.01034221,0.0007953419,0.00006450664,0.00006458328,0.01533655,0.00006542313,0.001862046],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002379518,"threshold_uncertainty_score":0.00796026,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01792547505564822,"score_gpt":0.2764582476630557,"score_spread":0.2585327726074075,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}