{"id":"W2954364011","doi":"10.1158/1538-7445.am2019-ct225","title":"Abstract CT225: A Phase Ib/IIa randomized pilot study to investigate the safety and tolerability of autologous T-cells with enhanced T-cell receptors specific to NY-ESO-1/LAGE-1a (GSK3377794) alone, or in combination with pembrolizumab, in advanced non-small cell lung cancer","year":2019,"lang":"en","type":"article","venue":"Cancer Research","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre Hospitalier de l’Université de Montréal; Princess Margaret Cancer Centre","funders":"","keywords":"Medicine; Pembrolizumab; Tolerability; Internal medicine; Oncology; Chemotherapy; Immunotherapy; Lung cancer; Phases of clinical research; Cancer; Adverse effect","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002413393,0.002526648,0.001977623,0.0004277532,0.0005814285,0.001333218,0.001077757,0.001782901,0.009973983],"category_scores_gemma":[0.001159353,0.0007488714,0.001298006,0.0005385882,0.001397996,0.001361832,0.0004979047,0.003499705,0.002157143],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00125773,"about_ca_system_score_gemma":0.002132181,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001401713,"about_ca_topic_score_gemma":0.003125301,"domain_scores_codex":[0.9992987,0.0003723086,0.00003787328,0.0001049591,0.00004960889,0.0001365398],"domain_scores_gemma":[0.9989676,0.0001376151,0.0001915746,0.00008528111,0.00006304472,0.0005548586],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9156203,0.0449509,0.001746081,0.0005317229,0.0008837544,0.0001433332,0.00008930921,0.0007042918,0.01896213,0.000167191,0.002535793,0.01366517],"study_design_scores_gemma":[0.7345347,0.2603281,0.002264761,0.00001799642,0.000290023,0.00008338987,0.00003089881,0.0003695767,0.001032528,0.00009766805,0.0009339899,0.0000162875],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9819993,0.001423746,0.0009110422,0.0006667405,0.000260521,0.009244051,0.002595555,0.0001747263,0.002724371],"genre_scores_gemma":[0.9770606,0.001076379,0.002053774,0.001574957,0.0003412859,0.01010545,0.003358186,0.00004421378,0.00438515],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.009973983,"threshold_uncertainty_score":0.03336626,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03804803893179919,"score_gpt":0.366386466464686,"score_spread":0.3283384275328868,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}