{"id":"W2954374242","doi":"10.1101/692129","title":"Drug screening to identify compounds to act as co-therapies for the treatment of pathogenic <i>Burkholderia</i>","year":2019,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Burkholderia infections and melioidosis","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Discovery Centre","funders":"Defence Science and Technology Laboratory; University of Exeter","keywords":"Burkholderia pseudomallei; Ceftazidime; Melioidosis; Burkholderia; Meropenem; Antibiotics; Microbiology; Medicine; Biology; Bacteria; Antibiotic resistance","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003653004,0.0007679248,0.0008762814,0.0008093694,0.0002534198,0.000526912,0.0004766117,0.0004566229,0.004370801],"category_scores_gemma":[0.0003490519,0.0002325043,0.0006059778,0.0007338229,0.0002087467,0.0003087852,0.0003283813,0.0006121458,0.001127018],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003788845,"about_ca_system_score_gemma":0.0004181781,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007718009,"about_ca_topic_score_gemma":0.002737237,"domain_scores_codex":[0.9997439,0.00006364583,0.00002003794,0.00004768575,0.00007331028,0.00005145886],"domain_scores_gemma":[0.9997811,0.00005838443,0.00003390429,0.00001720048,0.00007163124,0.00003789778],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0009345989,0.000927172,0.00207545,0.0009348257,0.0001233344,0.000407903,0.00005387552,0.003063083,0.9616184,0.0003222703,0.001406226,0.0281328],"study_design_scores_gemma":[0.0007629584,0.01803268,0.0136153,0.0002010192,0.0004994745,0.001740688,0.0001345576,0.007348865,0.9275991,0.0004025523,0.0295686,0.00009418291],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9333803,0.02379441,0.01780262,0.001145583,0.000207129,0.001949517,0.008033251,0.0009068523,0.0127803],"genre_scores_gemma":[0.9639737,0.008299124,0.01481357,0.0006146975,0.00004532795,0.0004334145,0.005409702,0.00005569886,0.006354882],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004370801,"threshold_uncertainty_score":0.01462179,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02916533144236308,"score_gpt":0.2966608991803703,"score_spread":0.2674955677380073,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}